FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1773284306> ?p ?o ?g. }

• W1773284306 endingPage "1618" @default.
• W1773284306 startingPage "1607" @default.
• W1773284306 abstract "Photodynamic treatment of the yeast Saccharomyces cerevisiae with the singlet oxygen sensitizer toluidine blue and visible light leads to rapid oxidation of ergosterol and accumulation of oxidized ergosterol derivatives in the plasma membrane. The predominant oxidation product accumulated was identified as 5alpha, 6alpha-epoxy-(22E)-ergosta-8,22-dien-3beta,7a lpha-diol (8-DED). 9(11)-dehydroergosterol (DHE) was identified as a minor oxidation product. In heat inactivated cells ergosterol is photooxidized to ergosterol epidioxide (EEP) and DHE. Disrupted cell preparations of S. cerevisiae convert EEP to 8-DED, and this activity is abolished in a boiled control indicating the presence of a membrane associated enzyme with an EEP isomerase activity. Yeast selectively mobilizes ergosterol from the intracellular sterol ester pool to replenish the level of free ergosterol in the plasma membrane during singlet oxygen oxidation. The following reaction pathway is proposed: singlet oxygen-mediated oxidation of ergosterol leads to mainly the formation of EEP, which is enzymatically rearranged to 8-DED. Ergosterol 7-hydroperoxide, a known minor product of the reaction of singlet oxygen with ergosterol, is formed at a much lower rate and decomposes to give DHE. Changes of physical properties of the plasma membrane are induced by depletion of ergosterol and accumulation of polar derivatives. Subsequent permeation of photosensitizer through the plasma membrane into the cell leads to events including impairment of mitochondrial function and cell inactivation." @default.
• W1773284306 created "2016-06-24" @default.
• W1773284306 creator A5002216696 @default.
• W1773284306 creator A5010237677 @default.
• W1773284306 creator A5039820336 @default.
• W1773284306 creator A5047065377 @default.
• W1773284306 creator A5058128586 @default.
• W1773284306 creator A5067157190 @default.
• W1773284306 date "2000-03-01" @default.
• W1773284306 modified "2023-10-11" @default.
• W1773284306 title "Effects of singlet oxygen on membrane sterols in the yeast Saccharomyces cerevisiae" @default.
• W1773284306 cites W1896630930 @default.
• W1773284306 cites W1927096570 @default.
• W1773284306 cites W1967186005 @default.
• W1773284306 cites W1969291683 @default.
• W1773284306 cites W1969327036 @default.
• W1773284306 cites W1969583685 @default.
• W1773284306 cites W1974623681 @default.
• W1773284306 cites W1983036663 @default.
• W1773284306 cites W1985300231 @default.
• W1773284306 cites W1986068920 @default.
• W1773284306 cites W1992389633 @default.
• W1773284306 cites W1994947653 @default.
• W1773284306 cites W1995660829 @default.
• W1773284306 cites W2003819393 @default.
• W1773284306 cites W2010067300 @default.
• W1773284306 cites W2011841402 @default.
• W1773284306 cites W2018017202 @default.
• W1773284306 cites W2021281614 @default.
• W1773284306 cites W2027998478 @default.
• W1773284306 cites W2028808504 @default.
• W1773284306 cites W2030505286 @default.
• W1773284306 cites W2036068456 @default.
• W1773284306 cites W2037106527 @default.
• W1773284306 cites W2057798842 @default.
• W1773284306 cites W2065543601 @default.
• W1773284306 cites W2072918524 @default.
• W1773284306 cites W2076164220 @default.
• W1773284306 cites W2091602891 @default.
• W1773284306 cites W2093978777 @default.
• W1773284306 cites W2101466066 @default.
• W1773284306 cites W2129828626 @default.
• W1773284306 cites W2130316063 @default.
• W1773284306 cites W2137926707 @default.
• W1773284306 cites W2147032776 @default.
• W1773284306 cites W2147571594 @default.
• W1773284306 cites W2157935239 @default.
• W1773284306 cites W2158339725 @default.
• W1773284306 cites W2158712876 @default.
• W1773284306 cites W2215618176 @default.
• W1773284306 cites W2346905841 @default.
• W1773284306 cites W2895408343 @default.
• W1773284306 cites W4253387890 @default.
• W1773284306 doi "https://doi.org/10.1046/j.1432-1327.2000.01179.x" @default.
• W1773284306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10712590" @default.
• W1773284306 hasPublicationYear "2000" @default.
• W1773284306 type Work @default.
• W1773284306 sameAs 1773284306 @default.
• W1773284306 citedByCount "78" @default.
• W1773284306 countsByYear W17732843062012 @default.
• W1773284306 countsByYear W17732843062013 @default.
• W1773284306 countsByYear W17732843062015 @default.
• W1773284306 countsByYear W17732843062016 @default.
• W1773284306 countsByYear W17732843062017 @default.
• W1773284306 countsByYear W17732843062018 @default.
• W1773284306 countsByYear W17732843062019 @default.
• W1773284306 countsByYear W17732843062020 @default.
• W1773284306 countsByYear W17732843062021 @default.
• W1773284306 countsByYear W17732843062022 @default.
• W1773284306 countsByYear W17732843062023 @default.
• W1773284306 crossrefType "journal-article" @default.
• W1773284306 hasAuthorship W1773284306A5002216696 @default.
• W1773284306 hasAuthorship W1773284306A5010237677 @default.
• W1773284306 hasAuthorship W1773284306A5039820336 @default.
• W1773284306 hasAuthorship W1773284306A5047065377 @default.
• W1773284306 hasAuthorship W1773284306A5058128586 @default.
• W1773284306 hasAuthorship W1773284306A5067157190 @default.
• W1773284306 hasBestOaLocation W17732843061 @default.
• W1773284306 hasConcept C178790620 @default.
• W1773284306 hasConcept C185592680 @default.
• W1773284306 hasConcept C2777516457 @default.
• W1773284306 hasConcept C2777576037 @default.
• W1773284306 hasConcept C2777910421 @default.
• W1773284306 hasConcept C2778163477 @default.
• W1773284306 hasConcept C2778718757 @default.
• W1773284306 hasConcept C2779222958 @default.
• W1773284306 hasConcept C2781469039 @default.
• W1773284306 hasConcept C41625074 @default.
• W1773284306 hasConcept C540031477 @default.
• W1773284306 hasConcept C55493867 @default.
• W1773284306 hasConcept C75473681 @default.
• W1773284306 hasConceptScore W1773284306C178790620 @default.
• W1773284306 hasConceptScore W1773284306C185592680 @default.
• W1773284306 hasConceptScore W1773284306C2777516457 @default.
• W1773284306 hasConceptScore W1773284306C2777576037 @default.
• W1773284306 hasConceptScore W1773284306C2777910421 @default.
• W1773284306 hasConceptScore W1773284306C2778163477 @default.
• W1773284306 hasConceptScore W1773284306C2778718757 @default.

• next