FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1773434774> ?p ?o ?g. }

• W1773434774 endingPage "649" @default.
• W1773434774 startingPage "638" @default.
• W1773434774 abstract "ABSTRACT The citrus flavonoids exhibit abilities to modulate the inflammatory response and carcinogenesis via several different mechanisms. We have studied the effects of two major citrus flavonoids – nobiletin (5,6,7,8,3′,4′-hexamethoxyflavone), and sinensetin (5,6,7,3′,4′-pentamethoxyflavone) on the spontaneous synthesis of nitric oxide (NO), succinate dehydrogenase (SDH) activity and the copper redox state of cytochrome c oxidase in human peripheral blood lymphocytes. Our results showed that in contrast to sinensetin, nobiletin causes a transient enhancement in the production of NO, which leads to a subsequent compensatory elevation of cytochrome c oxidase and SDH. High positive correlation between NO production and level of oxidation of copper in cytochrome oxidase and inverse correlation with the activity of SDH were found. We propose that temporal alterations of mitochondrial enzymes could mediate immunomodulatory and anticarcinogenic effects of nobiletin. PRACTICAL APPLICATIONS Positive correlation between nitric oxide production and level of oxidation of copper in cytochrome oxidase and inverse correlation with the activity of succinate dehydrogenase (SDH) were found in peripheral blood lymphocytes after treatment of cells by nobiletin. These results demonstrate that the beneficial immunomodulatory and anticarcinogenic effects of nobiletin possibly involve the transient inhibition of mitochondrial respiratory chain and subsequent compensatory elevation of SDH activity. Our findings indicate new steps in the molecular mechanism of nobiletin effects, suggesting new potential pharmacological actions of nutritional citrus flavonoids." @default.
• W1773434774 created "2016-06-24" @default.
• W1773434774 creator A5004353457 @default.
• W1773434774 creator A5019619250 @default.
• W1773434774 creator A5028718752 @default.
• W1773434774 creator A5045113082 @default.
• W1773434774 creator A5051244290 @default.
• W1773434774 creator A5059404564 @default.
• W1773434774 creator A5077361239 @default.
• W1773434774 date "2011-04-01" @default.
• W1773434774 modified "2023-09-27" @default.
• W1773434774 title "NOBILETIN TRANSIENTLY INCREASES THE PRODUCTION OF NITRIC OXIDE AND CHANGES THE ACTIVITY OF SUCCINATE DEHYDROGENASE IN HUMAN BLOOD LYMPHOCYTES" @default.
• W1773434774 cites W1489253375 @default.
• W1773434774 cites W1539954440 @default.
• W1773434774 cites W1953358365 @default.
• W1773434774 cites W1990802251 @default.
• W1773434774 cites W1996782427 @default.
• W1773434774 cites W1999640621 @default.
• W1773434774 cites W2003526590 @default.
• W1773434774 cites W2008624998 @default.
• W1773434774 cites W2032890845 @default.
• W1773434774 cites W2035164721 @default.
• W1773434774 cites W2041596211 @default.
• W1773434774 cites W2042198607 @default.
• W1773434774 cites W2048626265 @default.
• W1773434774 cites W2050512229 @default.
• W1773434774 cites W2055821573 @default.
• W1773434774 cites W2056522555 @default.
• W1773434774 cites W2057199368 @default.
• W1773434774 cites W2065016765 @default.
• W1773434774 cites W2066022538 @default.
• W1773434774 cites W2070342882 @default.
• W1773434774 cites W2073003808 @default.
• W1773434774 cites W2075274292 @default.
• W1773434774 cites W2091380103 @default.
• W1773434774 cites W2095069375 @default.
• W1773434774 cites W2096668981 @default.
• W1773434774 cites W2107843297 @default.
• W1773434774 cites W2107911729 @default.
• W1773434774 cites W2109335148 @default.
• W1773434774 cites W2130514425 @default.
• W1773434774 cites W2135068351 @default.
• W1773434774 cites W2147137265 @default.
• W1773434774 cites W4296766471 @default.
• W1773434774 doi "https://doi.org/10.1111/j.1745-4514.2010.00407.x" @default.
• W1773434774 hasPublicationYear "2011" @default.
• W1773434774 type Work @default.
• W1773434774 sameAs 1773434774 @default.
• W1773434774 citedByCount "4" @default.
• W1773434774 countsByYear W17734347742014 @default.
• W1773434774 countsByYear W17734347742016 @default.
• W1773434774 countsByYear W17734347742021 @default.
• W1773434774 crossrefType "journal-article" @default.
• W1773434774 hasAuthorship W1773434774A5004353457 @default.
• W1773434774 hasAuthorship W1773434774A5019619250 @default.
• W1773434774 hasAuthorship W1773434774A5028718752 @default.
• W1773434774 hasAuthorship W1773434774A5045113082 @default.
• W1773434774 hasAuthorship W1773434774A5051244290 @default.
• W1773434774 hasAuthorship W1773434774A5059404564 @default.
• W1773434774 hasAuthorship W1773434774A5077361239 @default.
• W1773434774 hasBestOaLocation W17734347741 @default.
• W1773434774 hasConcept C123249941 @default.
• W1773434774 hasConcept C178790620 @default.
• W1773434774 hasConcept C185592680 @default.
• W1773434774 hasConcept C2778004101 @default.
• W1773434774 hasConcept C2778401301 @default.
• W1773434774 hasConcept C2779054382 @default.
• W1773434774 hasConcept C2781330172 @default.
• W1773434774 hasConcept C28859421 @default.
• W1773434774 hasConcept C519581460 @default.
• W1773434774 hasConcept C55493867 @default.
• W1773434774 hasConcept C86803240 @default.
• W1773434774 hasConcept C98274493 @default.
• W1773434774 hasConceptScore W1773434774C123249941 @default.
• W1773434774 hasConceptScore W1773434774C178790620 @default.
• W1773434774 hasConceptScore W1773434774C185592680 @default.
• W1773434774 hasConceptScore W1773434774C2778004101 @default.
• W1773434774 hasConceptScore W1773434774C2778401301 @default.
• W1773434774 hasConceptScore W1773434774C2779054382 @default.
• W1773434774 hasConceptScore W1773434774C2781330172 @default.
• W1773434774 hasConceptScore W1773434774C28859421 @default.
• W1773434774 hasConceptScore W1773434774C519581460 @default.
• W1773434774 hasConceptScore W1773434774C55493867 @default.
• W1773434774 hasConceptScore W1773434774C86803240 @default.
• W1773434774 hasConceptScore W1773434774C98274493 @default.
• W1773434774 hasIssue "2" @default.
• W1773434774 hasLocation W17734347741 @default.
• W1773434774 hasOpenAccess W1773434774 @default.
• W1773434774 hasPrimaryLocation W17734347741 @default.
• W1773434774 hasRelatedWork W1773434774 @default.
• W1773434774 hasRelatedWork W1857673344 @default.
• W1773434774 hasRelatedWork W1976564273 @default.
• W1773434774 hasRelatedWork W2000229428 @default.
• W1773434774 hasRelatedWork W2068360154 @default.
• W1773434774 hasRelatedWork W2315867336 @default.
• W1773434774 hasRelatedWork W2390442379 @default.
• W1773434774 hasRelatedWork W2404633264 @default.
• W1773434774 hasRelatedWork W2470010346 @default.

• next