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- W1773515121 abstract "This chapter summarizes recent information on the function of high-mobility-group (HMG) proteins. Advances in this field were made primarily by elucidating the structure of these proteins and by understanding their mode of interactions with DNA and chromatin. Renewed interest in these proteins is because of the finding that the DNA-binding domains of many regulatory proteins share common elements with the HMG-1/-2 chromosomal protein family. The HMG proteins are among the largest and best characterized group of nonhistone chromosomal proteins. Members of this protein group are found in all the cells of higher eukaryotes. Most of the data suggest that HMG proteins are associated with selected regions in chromatin and this association affects the architecture and increases the structural complexity of the chromatin fiber. The human HMG-I(Y) gene is located on the short arm of chromosome 6 in a region involved in rearrangements, translocations, and other abnormalities correlated with a number of human cancers." @default.
- W1773515121 created "2016-06-24" @default.
- W1773515121 creator A5039096120 @default.
- W1773515121 creator A5070796998 @default.
- W1773515121 date "1996-01-01" @default.
- W1773515121 modified "2023-09-27" @default.
- W1773515121 title "High-Mobility-Group Chromosomal Proteins: Architectural Components That Facilitate Chromatin Function" @default.
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