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• W177369191 abstract "Event Abstract Back to Event Input-specific distribution of A-type potassium channels in the thalamus. Hajnalka Bokor1*, Kristof Giber1, Mihaly Kollo1, Zoltan Nusser1 and Laszlo Acsady1 1 Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungary Potassium channels formed by Kv4.2 and Kv4.3 subunits are responsible for a transient K+ current, the A-current in the brain, playing an important role in the integrative properties of dendrites. In the present study the so far unknown thalamic distribution of these subunits were studied. Kv4.2/Kv4.3 subunits formed strongly immunoreactive clusters on proximal dendrites of relay cells with largest accumulation in spine-like dendritic appendages in the ventral posteromedial nucleus (VPM) but not in the posterior nucleus (Po) or in the ventrolateral part of VPM (VPMvl). Double immunostaining with a marker for sensory afferents and either Kv subunits revealed at light- and electron microscopic level that Kv-clusters are present almost exclusively postsynaptic to large subcortical terminals and almost all of these terminals faced Kv-rich dendritic segments in the VPM. In the proximal dendrites of VPM the density of Kv immunogold labeling was 20 times higher on the membrane surfaces covered by sensory afferents compared to surfaces free of the input. During ontogeny Kv4.2/4.3-clusters developed in line with the ascending sensory pathway, were absent at P0-P5 but were fully developed at P24. Following lesion of the PrV, clusters selectively disappeared postsynaptic to degenerating terminals but were unaffected in dendrites contacted by intact terminals. Our data demonstrate input specific accumulation of A-type potassium channels in thalamic relay cell dendrites. The strong association of large subcortical afferents with postsynapitic Kv4.2/Kv4.3 subunits suggests an effective curtailing of lemniscal sensory EPSPs by A-type K current contrary to paralemniscal and cortical diver EPSPs in VPMvl and Po. Conference: 12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009. Presentation Type: Poster Presentation Topic: Developmental neurobiology and subcortical functions Citation: Bokor H, Giber K, Kollo M, Nusser Z and Acsady L (2009). Input-specific distribution of A-type potassium channels in the thalamus.. Front. Syst. Neurosci. Conference Abstract: 12th Meeting of the Hungarian Neuroscience Society. doi: 10.3389/conf.neuro.01.2009.04.048 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Feb 2009; Published Online: 27 Feb 2009. * Correspondence: Hajnalka Bokor, Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Budapest, Hungary, hbokor@koki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Hajnalka Bokor Kristof Giber Mihaly Kollo Zoltan Nusser Laszlo Acsady Google Hajnalka Bokor Kristof Giber Mihaly Kollo Zoltan Nusser Laszlo Acsady Google Scholar Hajnalka Bokor Kristof Giber Mihaly Kollo Zoltan Nusser Laszlo Acsady PubMed Hajnalka Bokor Kristof Giber Mihaly Kollo Zoltan Nusser Laszlo Acsady Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W177369191 date "2009-01-01" @default.
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• W177369191 title "Input-specific distribution of A-type potassium channels in the thalamus." @default.
• W177369191 doi "https://doi.org/10.3389/conf.neuro.01.2009.04.048" @default.
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