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• W1773891902 startingPage "6478" @default.
• W1773891902 abstract "Sensitization is a form of nonassociative learning in which a strong or noxious stimulus persistently enhances the response produced by a weaker stimulus. In the leech Hirudo medicinalis, the S-interneuron is required for sensitization of the shortening response. A single S-cell axon was surgically separated from its sole synaptic partner, the neighboring S-cell. This consistently eliminated sensitization without impairing reflexive shortening itself, as measured in semi-intact specimens. Sensitization of the shortening reflex returned after 3 weeks when the severed axon grew and regenerated its specific electrical synapse within the nerve cord, as shown by restored conduction of impulses between S-cells. This confirms the essential role of one neuron, the S-cell, in sensitization, and it demonstrates that regeneration of the synapse between S-cells restores this example of nonassociative learning." @default.
• W1773891902 created "2016-06-24" @default.
• W1773891902 creator A5011098892 @default.
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• W1773891902 date "1997-08-15" @default.
• W1773891902 modified "2023-09-23" @default.
• W1773891902 title "Regeneration of a central synapse restores nonassociative learning." @default.
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• W1773891902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6568365" @default.
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