FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1774019889> ?p ?o ?g. }

• W1774019889 endingPage "7069" @default.
• W1774019889 startingPage "7058" @default.
• W1774019889 abstract "In order to catalyse the splicing of messenger RNA, multiple proteins and RNA components associate and dissociate in a dynamic highly choreographed process. The Prp19 complex is a conserved essential part of the splicing machinery thought to facilitate the conformational changes the spliceosome undergoes during catalysis. Dynamic protein interactions often involve highly disordered regions that are difficult to study by structural methods. Using amine crosslinking and hydrogen-deuterium exchange coupled to mass spectrometry, we describe the architecture of the Prp19 sub-complex that contains CTNNBL1. Deficiency in CTNNBL1 leads to delayed initiation of cell division and embryonic lethality. Here we show that in vitro CTNNBL1 enhances the association of CWC15 and CDC5L, both core Prp19 complex proteins and identify an overlap in the region of CDC5L that binds either CTNNBL1 or CWC15 suggesting the two proteins might exchange places in the complex. Furthermore, in vivo, CTNNBL1 is required to maintain normal levels of the Prp19 complex and to facilitate the interaction of CWC15 with CDC5L. Our results identify a chaperone function for CTNNBL1 within the essential Prp19 complex, a function required to maintain the integrity of the complex and to support efficient splicing." @default.
• W1774019889 created "2016-06-24" @default.
• W1774019889 creator A5014354294 @default.
• W1774019889 creator A5044165303 @default.
• W1774019889 creator A5054269276 @default.
• W1774019889 creator A5057339074 @default.
• W1774019889 creator A5058501664 @default.
• W1774019889 creator A5085306084 @default.
• W1774019889 creator A5088164398 @default.
• W1774019889 date "2015-06-29" @default.
• W1774019889 modified "2023-10-07" @default.
• W1774019889 title "CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex" @default.
• W1774019889 cites W121766353 @default.
• W1774019889 cites W1966686696 @default.
• W1774019889 cites W1974717425 @default.
• W1774019889 cites W1981650365 @default.
• W1774019889 cites W1982878502 @default.
• W1774019889 cites W1983668342 @default.
• W1774019889 cites W1985475442 @default.
• W1774019889 cites W1990464227 @default.
• W1774019889 cites W1993455758 @default.
• W1774019889 cites W1998419287 @default.
• W1774019889 cites W2002976991 @default.
• W1774019889 cites W2006729631 @default.
• W1774019889 cites W2008525795 @default.
• W1774019889 cites W2017682994 @default.
• W1774019889 cites W2019239252 @default.
• W1774019889 cites W2026902836 @default.
• W1774019889 cites W2030516478 @default.
• W1774019889 cites W2034203606 @default.
• W1774019889 cites W2044749033 @default.
• W1774019889 cites W2052948442 @default.
• W1774019889 cites W2057908300 @default.
• W1774019889 cites W2074634070 @default.
• W1774019889 cites W2077690493 @default.
• W1774019889 cites W2080878856 @default.
• W1774019889 cites W2082078734 @default.
• W1774019889 cites W2091377102 @default.
• W1774019889 cites W2101134838 @default.
• W1774019889 cites W2101204654 @default.
• W1774019889 cites W2101626961 @default.
• W1774019889 cites W2113039254 @default.
• W1774019889 cites W2117073299 @default.
• W1774019889 cites W2117320292 @default.
• W1774019889 cites W2123203780 @default.
• W1774019889 cites W2123289678 @default.
• W1774019889 cites W2125660791 @default.
• W1774019889 cites W2127843422 @default.
• W1774019889 cites W2130459692 @default.
• W1774019889 cites W2143350291 @default.
• W1774019889 cites W2148864927 @default.
• W1774019889 cites W2152729793 @default.
• W1774019889 cites W2161774584 @default.
• W1774019889 cites W2167023949 @default.
• W1774019889 cites W2168915479 @default.
• W1774019889 cites W2313059120 @default.
• W1774019889 doi "https://doi.org/10.1093/nar/gkv643" @default.
• W1774019889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4538830" @default.
• W1774019889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26130721" @default.
• W1774019889 hasPublicationYear "2015" @default.
• W1774019889 type Work @default.
• W1774019889 sameAs 1774019889 @default.
• W1774019889 citedByCount "15" @default.
• W1774019889 countsByYear W17740198892017 @default.
• W1774019889 countsByYear W17740198892018 @default.
• W1774019889 countsByYear W17740198892019 @default.
• W1774019889 countsByYear W17740198892020 @default.
• W1774019889 countsByYear W17740198892021 @default.
• W1774019889 countsByYear W17740198892022 @default.
• W1774019889 countsByYear W17740198892023 @default.
• W1774019889 crossrefType "journal-article" @default.
• W1774019889 hasAuthorship W1774019889A5014354294 @default.
• W1774019889 hasAuthorship W1774019889A5044165303 @default.
• W1774019889 hasAuthorship W1774019889A5054269276 @default.
• W1774019889 hasAuthorship W1774019889A5057339074 @default.
• W1774019889 hasAuthorship W1774019889A5058501664 @default.
• W1774019889 hasAuthorship W1774019889A5085306084 @default.
• W1774019889 hasAuthorship W1774019889A5088164398 @default.
• W1774019889 hasBestOaLocation W17740198891 @default.
• W1774019889 hasConcept C104317684 @default.
• W1774019889 hasConcept C34905852 @default.
• W1774019889 hasConcept C40000846 @default.
• W1774019889 hasConcept C46111723 @default.
• W1774019889 hasConcept C54355233 @default.
• W1774019889 hasConcept C54458228 @default.
• W1774019889 hasConcept C67705224 @default.
• W1774019889 hasConcept C70721500 @default.
• W1774019889 hasConcept C86803240 @default.
• W1774019889 hasConcept C95444343 @default.
• W1774019889 hasConceptScore W1774019889C104317684 @default.
• W1774019889 hasConceptScore W1774019889C34905852 @default.
• W1774019889 hasConceptScore W1774019889C40000846 @default.
• W1774019889 hasConceptScore W1774019889C46111723 @default.
• W1774019889 hasConceptScore W1774019889C54355233 @default.
• W1774019889 hasConceptScore W1774019889C54458228 @default.
• W1774019889 hasConceptScore W1774019889C67705224 @default.
• W1774019889 hasConceptScore W1774019889C70721500 @default.
• W1774019889 hasConceptScore W1774019889C86803240 @default.

• next