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• W1774176118 abstract "Using intracellular recording techniques in CA1 cells in the hippocampal slice, we studied the responses of cells to synaptically released and iontophoretically applied GABA. With high-resistance, Cl(- )-filled electrodes, which inverted and enlarged the responses at normal resting potentials, we examined spontaneous GABA-mediated IPSPs. Usually we recorded the spontaneous events in the presence of carbachol (10–25 microM), which significantly increased IPSP frequency and blocked potentially confounding K+ conductances. Following a train of action potentials, spontaneous IPSPs were transiently suppressed. This suppression could not be accounted for by membrane conductance changes following the train or activation of a recurrent circuit. Whole-cell voltage-clamp recordings in the slice indicated that the amplitudes of the spontaneous GABAA inhibitory postsynaptic currents (IPSCs) were also diminished following the action potential train. In some cases BAY K 8644, a Ca2+ channel agonist, enhanced the suppression of IPSPs, while buffering changes in [Ca2+]i with EGTA or BAPTA prevented it. The monosynaptically evoked IPSC in the presence of 6-cyano-7- nitroquinoxaline-2,3-dione (CNQX) and dl-2-amino-5-phosphonovaleric acid (APN) was also diminished following a train of action potentials; however, iontophoretically applied GABA responses did not change significantly. These studies suggest that localized physiological changes in postsynaptic [Ca2+]i potently modulate synaptic GABAA inputs and that this modulation may be an important regulatory mechanism in mammalian brain." @default.
• W1774176118 created "2016-06-24" @default.
• W1774176118 creator A5015269712 @default.
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• W1774176118 date "1992-10-01" @default.
• W1774176118 modified "2023-09-30" @default.
• W1774176118 title "Postsynaptic spike firing reduces synaptic GABAA responses in hippocampal pyramidal cells" @default.
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• W1774176118 doi "https://doi.org/10.1523/jneurosci.12-10-04122.1992" @default.
• W1774176118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6575956" @default.
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