FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1774672014> ?p ?o ?g. }

• W1774672014 endingPage "333" @default.
• W1774672014 startingPage "326" @default.
• W1774672014 abstract "Objectives Tangible clinical benefit is achieved in only a relatively small proportion of extensive-stage small cell lung cancer (SCLC) patients receiving current treatment strategies. Therefore, a more personalized use of current and novel treatment approaches is of critical importance. Individualized therapy relies on the identification of specific biomarkers predictive of response to a particular type of cancer treatment. Immune-related parameters emerge as powerful biomarkers among a variety of predictors of clinical response to various types of cancer treatment. Patients and methods Using multicolor flow cytometry, we evaluated a predictive value of CD8highCD57+ T-cell population and its immunosuppressive (FOXP3+, NKG2A+) and cytotoxic (Perforin+) subsets in the peripheral blood of extensive-stage SCLC patients (n = 82) treated with either chemotherapy-alone (n = 24), or chemoradiation therapy (n = 42), or receiving best supportive care (n = 16). Results The low level (<20%) of CD8highCD57+ T cells within the peripheral blood CD8+ T-cell population and the low level (<3%) of the immunosuppressive FOXP3-positive subset within the CD8highCD57+ T-cell population were independent predictors of a better response to treatment with chemoradiation therapy, but not with chemotherapy alone or best supportive care. Importantly there was no significant survival difference between SCLC patients who were: (i) treated with chemoradiation, but had an unfavourable immune profile (≥20% of CD8highCD57+ T cells and ≥3% of its FOXP3-positive subset), (ii) treated with chemotherapy alone, or (iii) received best supportive care. Conclusions We show that only a combination of chemotherapy with radiation therapy offered a considerable survival benefit that was confined to a subset of extensive-stage SCLC patients with a favourable predictive immune profile in the peripheral blood." @default.
• W1774672014 created "2016-06-24" @default.
• W1774672014 creator A5018082957 @default.
• W1774672014 creator A5023713952 @default.
• W1774672014 creator A5045656640 @default.
• W1774672014 creator A5057881052 @default.
• W1774672014 creator A5073138141 @default.
• W1774672014 creator A5085053246 @default.
• W1774672014 creator A5085165502 @default.
• W1774672014 creator A5089413758 @default.
• W1774672014 date "2015-11-01" @default.
• W1774672014 modified "2023-10-17" @default.
• W1774672014 title "CD8highCD57+ T-cell population as an independent predictor of response to chemoradiation therapy in extensive-stage small cell lung cancer" @default.
• W1774672014 cites W1526040652 @default.
• W1774672014 cites W1558352705 @default.
• W1774672014 cites W1593813009 @default.
• W1774672014 cites W1906792572 @default.
• W1774672014 cites W1907865033 @default.
• W1774672014 cites W1910638072 @default.
• W1774672014 cites W1950892723 @default.
• W1774672014 cites W1978105087 @default.
• W1774672014 cites W1983437058 @default.
• W1774672014 cites W1990424629 @default.
• W1774672014 cites W1991396100 @default.
• W1774672014 cites W1995635599 @default.
• W1774672014 cites W1996378082 @default.
• W1774672014 cites W2009098155 @default.
• W1774672014 cites W2017251888 @default.
• W1774672014 cites W2023980114 @default.
• W1774672014 cites W2028727579 @default.
• W1774672014 cites W2029046266 @default.
• W1774672014 cites W2044765390 @default.
• W1774672014 cites W2045751308 @default.
• W1774672014 cites W2053929975 @default.
• W1774672014 cites W2067384676 @default.
• W1774672014 cites W2068543449 @default.
• W1774672014 cites W2070440255 @default.
• W1774672014 cites W2072502005 @default.
• W1774672014 cites W2073514389 @default.
• W1774672014 cites W2074221799 @default.
• W1774672014 cites W2074632761 @default.
• W1774672014 cites W2083295790 @default.
• W1774672014 cites W2086591619 @default.
• W1774672014 cites W2096244608 @default.
• W1774672014 cites W2096984065 @default.
• W1774672014 cites W2101585919 @default.
• W1774672014 cites W2120277401 @default.
• W1774672014 cites W2125334994 @default.
• W1774672014 cites W2126060249 @default.
• W1774672014 cites W2129526644 @default.
• W1774672014 cites W2131664752 @default.
• W1774672014 cites W2140683554 @default.
• W1774672014 cites W2145583195 @default.
• W1774672014 cites W2146375469 @default.
• W1774672014 cites W2146947563 @default.
• W1774672014 cites W2152093797 @default.
• W1774672014 cites W2154323253 @default.
• W1774672014 cites W2155128787 @default.
• W1774672014 cites W2329365547 @default.
• W1774672014 cites W2412440172 @default.
• W1774672014 doi "https://doi.org/10.1016/j.lungcan.2015.08.001" @default.
• W1774672014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26319316" @default.
• W1774672014 hasPublicationYear "2015" @default.
• W1774672014 type Work @default.
• W1774672014 sameAs 1774672014 @default.
• W1774672014 citedByCount "3" @default.
• W1774672014 countsByYear W17746720142016 @default.
• W1774672014 countsByYear W17746720142017 @default.
• W1774672014 crossrefType "journal-article" @default.
• W1774672014 hasAuthorship W1774672014A5018082957 @default.
• W1774672014 hasAuthorship W1774672014A5023713952 @default.
• W1774672014 hasAuthorship W1774672014A5045656640 @default.
• W1774672014 hasAuthorship W1774672014A5057881052 @default.
• W1774672014 hasAuthorship W1774672014A5073138141 @default.
• W1774672014 hasAuthorship W1774672014A5085053246 @default.
• W1774672014 hasAuthorship W1774672014A5085165502 @default.
• W1774672014 hasAuthorship W1774672014A5089413758 @default.
• W1774672014 hasConcept C121608353 @default.
• W1774672014 hasConcept C126322002 @default.
• W1774672014 hasConcept C143998085 @default.
• W1774672014 hasConcept C146357865 @default.
• W1774672014 hasConcept C151730666 @default.
• W1774672014 hasConcept C167672396 @default.
• W1774672014 hasConcept C203014093 @default.
• W1774672014 hasConcept C2776256026 @default.
• W1774672014 hasConcept C2776694085 @default.
• W1774672014 hasConcept C2908647359 @default.
• W1774672014 hasConcept C509974204 @default.
• W1774672014 hasConcept C71924100 @default.
• W1774672014 hasConcept C86803240 @default.
• W1774672014 hasConcept C8891405 @default.
• W1774672014 hasConcept C99454951 @default.
• W1774672014 hasConceptScore W1774672014C121608353 @default.
• W1774672014 hasConceptScore W1774672014C126322002 @default.
• W1774672014 hasConceptScore W1774672014C143998085 @default.
• W1774672014 hasConceptScore W1774672014C146357865 @default.
• W1774672014 hasConceptScore W1774672014C151730666 @default.
• W1774672014 hasConceptScore W1774672014C167672396 @default.

• next