FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1774796561> ?p ?o ?g. }

• W1774796561 endingPage "4114" @default.
• W1774796561 startingPage "4105" @default.
• W1774796561 abstract "Adrenal glucocorticoid hormones are potent modulators of brain function in the context of acute and chronic stress. Both mineralocorticoid (MRs) and glucocorticoid receptors (GRs) can mediate these effects. We studied the brain effects of a novel ligand, C118335, with high affinity for GRs and modest affinity for MRs. In vitro profiling of receptor-coregulator interactions suggested that the compound is a “selective modulator” type compound for GRs that can have both agonistic and antagonistic effects. Its molecular profile for MRs was highly similar to those of the full antagonists spironolactone and eplerenone. C118335 showed predominantly antagonistic effects on hippocampal mRNA regulation of known glucocorticoid target genes. Likewise, systemic administration of C118335 blocked the GR-mediated posttraining corticosterone-induced enhancement of memory consolidation in an inhibitory avoidance task. Posttraining administration of C118335, however, gave a strong and dose-dependent impairment of memory consolidation that, surprisingly, reflected involvement of MRs and not GRs. Finally, C118335 treatment acutely suppressed the hypothalamus-pituitary-adrenal axis as measured by plasma corticosterone levels. Mixed GR/MR ligands, such as C118335, can be used to unravel the mechanisms of glucocorticoid signaling. The compound is also a prototype of mixed GR/MR ligands that might alleviate the harmful effects of chronic overexposure to endogenous glucocorticoids." @default.
• W1774796561 created "2016-06-24" @default.
• W1774796561 creator A5004034366 @default.
• W1774796561 creator A5010207048 @default.
• W1774796561 creator A5025954248 @default.
• W1774796561 creator A5031595865 @default.
• W1774796561 creator A5033686591 @default.
• W1774796561 creator A5039593796 @default.
• W1774796561 creator A5042351326 @default.
• W1774796561 creator A5045828654 @default.
• W1774796561 creator A5048946062 @default.
• W1774796561 creator A5068994703 @default.
• W1774796561 creator A5072205648 @default.
• W1774796561 date "2015-08-25" @default.
• W1774796561 modified "2023-10-16" @default.
• W1774796561 title "A Mixed Glucocorticoid/Mineralocorticoid Selective Modulator With Dominant Antagonism in the Male Rat Brain" @default.
• W1774796561 cites W1966298771 @default.
• W1774796561 cites W1968534535 @default.
• W1774796561 cites W1971552605 @default.
• W1774796561 cites W1977518774 @default.
• W1774796561 cites W1983407559 @default.
• W1774796561 cites W1986381796 @default.
• W1774796561 cites W1987840185 @default.
• W1774796561 cites W1995933145 @default.
• W1774796561 cites W1997655511 @default.
• W1774796561 cites W2003050811 @default.
• W1774796561 cites W2003196551 @default.
• W1774796561 cites W2005344166 @default.
• W1774796561 cites W2005789597 @default.
• W1774796561 cites W2008301967 @default.
• W1774796561 cites W2011419691 @default.
• W1774796561 cites W2022990742 @default.
• W1774796561 cites W2025075171 @default.
• W1774796561 cites W2038487059 @default.
• W1774796561 cites W2038519619 @default.
• W1774796561 cites W2040669411 @default.
• W1774796561 cites W2044045263 @default.
• W1774796561 cites W2054429624 @default.
• W1774796561 cites W2058105213 @default.
• W1774796561 cites W2059167203 @default.
• W1774796561 cites W2069353840 @default.
• W1774796561 cites W2071129618 @default.
• W1774796561 cites W2074802748 @default.
• W1774796561 cites W2078132872 @default.
• W1774796561 cites W2090776417 @default.
• W1774796561 cites W2093147895 @default.
• W1774796561 cites W2095060581 @default.
• W1774796561 cites W2095590290 @default.
• W1774796561 cites W2097578495 @default.
• W1774796561 cites W2108244474 @default.
• W1774796561 cites W2113112889 @default.
• W1774796561 cites W2116629441 @default.
• W1774796561 cites W2126352457 @default.
• W1774796561 cites W2133177768 @default.
• W1774796561 cites W2138827102 @default.
• W1774796561 cites W2143964833 @default.
• W1774796561 cites W2155636817 @default.
• W1774796561 cites W2155673708 @default.
• W1774796561 cites W2158321995 @default.
• W1774796561 cites W2161618887 @default.
• W1774796561 cites W2166381668 @default.
• W1774796561 cites W2166623778 @default.
• W1774796561 cites W2169446553 @default.
• W1774796561 cites W2222059780 @default.
• W1774796561 cites W2417497674 @default.
• W1774796561 cites W4253861185 @default.
• W1774796561 doi "https://doi.org/10.1210/en.2015-1390" @default.
• W1774796561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26305887" @default.
• W1774796561 hasPublicationYear "2015" @default.
• W1774796561 type Work @default.
• W1774796561 sameAs 1774796561 @default.
• W1774796561 citedByCount "46" @default.
• W1774796561 countsByYear W17747965612015 @default.
• W1774796561 countsByYear W17747965612016 @default.
• W1774796561 countsByYear W17747965612017 @default.
• W1774796561 countsByYear W17747965612018 @default.
• W1774796561 countsByYear W17747965612019 @default.
• W1774796561 countsByYear W17747965612020 @default.
• W1774796561 countsByYear W17747965612021 @default.
• W1774796561 countsByYear W17747965612022 @default.
• W1774796561 countsByYear W17747965612023 @default.
• W1774796561 crossrefType "journal-article" @default.
• W1774796561 hasAuthorship W1774796561A5004034366 @default.
• W1774796561 hasAuthorship W1774796561A5010207048 @default.
• W1774796561 hasAuthorship W1774796561A5025954248 @default.
• W1774796561 hasAuthorship W1774796561A5031595865 @default.
• W1774796561 hasAuthorship W1774796561A5033686591 @default.
• W1774796561 hasAuthorship W1774796561A5039593796 @default.
• W1774796561 hasAuthorship W1774796561A5042351326 @default.
• W1774796561 hasAuthorship W1774796561A5045828654 @default.
• W1774796561 hasAuthorship W1774796561A5048946062 @default.
• W1774796561 hasAuthorship W1774796561A5068994703 @default.
• W1774796561 hasAuthorship W1774796561A5072205648 @default.
• W1774796561 hasBestOaLocation W17747965611 @default.
• W1774796561 hasConcept C126322002 @default.
• W1774796561 hasConcept C134018914 @default.
• W1774796561 hasConcept C148762608 @default.
• W1774796561 hasConcept C151730666 @default.

• next