Matches in SemOpenAlex for { <https://semopenalex.org/work/W1774946543> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1774946543 endingPage "22" @default.
- W1774946543 startingPage "22" @default.
- W1774946543 abstract "New genetic methods have made it possible to substitute cone pigments in the retinas of adult nonhuman primates. Doing so influences the animals' visual abilities, demonstrating that the gene therapy was effective. However, we argue that no studies conducted so far have unambiguously demonstrated that the experimental animals have also acquired the ability to make new color distinctions. Simply put, it has been shown that animals that underwent the gene treatment can now—in addition to finding a red ball on a grayish background—find a green ball on a grayish background. However, it has not been shown that the animals can distinguish a red ball from a green one. For most people, that essential ability would be the primary reason for wanting to undergo a treatment for color-blindness in the first place, for instance, because their color-blindness currently prevents them from pursuing a career as a pilot or firefighter. It is important to point out such possible limitations of gene therapy for color-blindness to avoid unwarranted expectations in both clinicians and patients. To explain the origin of our concerns, we simulate how replacing the pigment of some cones is expected to influence the outcomes on the behavioral test used so far. The simulations show that this test does not provide conclusive evidence that the animals acquired the ability to make new chromatic distinctions. In our view, it is therefore premature to claim that human color-blindness can be cured through gene therapy. We propose a test that would provide more conclusive evidence of fundamentally altered color vision after gene therapy." @default.
- W1774946543 created "2016-06-24" @default.
- W1774946543 creator A5018709359 @default.
- W1774946543 creator A5055183223 @default.
- W1774946543 date "2015-09-29" @default.
- W1774946543 modified "2023-09-26" @default.
- W1774946543 title "Is adding a new class of cones to the retina sufficient to cure color-blindness?" @default.
- W1774946543 cites W1870538900 @default.
- W1774946543 cites W1965463920 @default.
- W1774946543 cites W1969553775 @default.
- W1774946543 cites W1971992697 @default.
- W1774946543 cites W1974457453 @default.
- W1774946543 cites W1985522494 @default.
- W1774946543 cites W1991051444 @default.
- W1774946543 cites W1995319228 @default.
- W1774946543 cites W2004028908 @default.
- W1774946543 cites W2008625057 @default.
- W1774946543 cites W2017422450 @default.
- W1774946543 cites W2046913501 @default.
- W1774946543 cites W2060049127 @default.
- W1774946543 cites W2069773437 @default.
- W1774946543 cites W2070909031 @default.
- W1774946543 cites W2072040663 @default.
- W1774946543 cites W2073901784 @default.
- W1774946543 cites W2080335044 @default.
- W1774946543 cites W2090736342 @default.
- W1774946543 cites W2093489762 @default.
- W1774946543 cites W2105555292 @default.
- W1774946543 cites W2105717026 @default.
- W1774946543 cites W2114564223 @default.
- W1774946543 cites W2161102495 @default.
- W1774946543 doi "https://doi.org/10.1167/15.13.22" @default.
- W1774946543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26418498" @default.
- W1774946543 hasPublicationYear "2015" @default.
- W1774946543 type Work @default.
- W1774946543 sameAs 1774946543 @default.
- W1774946543 citedByCount "5" @default.
- W1774946543 countsByYear W17749465432019 @default.
- W1774946543 countsByYear W17749465432020 @default.
- W1774946543 countsByYear W17749465432022 @default.
- W1774946543 crossrefType "journal-article" @default.
- W1774946543 hasAuthorship W1774946543A5018709359 @default.
- W1774946543 hasAuthorship W1774946543A5055183223 @default.
- W1774946543 hasBestOaLocation W17749465431 @default.
- W1774946543 hasConcept C119767625 @default.
- W1774946543 hasConcept C120665830 @default.
- W1774946543 hasConcept C121332964 @default.
- W1774946543 hasConcept C154945302 @default.
- W1774946543 hasConcept C15744967 @default.
- W1774946543 hasConcept C180747234 @default.
- W1774946543 hasConcept C196956537 @default.
- W1774946543 hasConcept C2780929884 @default.
- W1774946543 hasConcept C41008148 @default.
- W1774946543 hasConcept C61674017 @default.
- W1774946543 hasConcept C71924100 @default.
- W1774946543 hasConceptScore W1774946543C119767625 @default.
- W1774946543 hasConceptScore W1774946543C120665830 @default.
- W1774946543 hasConceptScore W1774946543C121332964 @default.
- W1774946543 hasConceptScore W1774946543C154945302 @default.
- W1774946543 hasConceptScore W1774946543C15744967 @default.
- W1774946543 hasConceptScore W1774946543C180747234 @default.
- W1774946543 hasConceptScore W1774946543C196956537 @default.
- W1774946543 hasConceptScore W1774946543C2780929884 @default.
- W1774946543 hasConceptScore W1774946543C41008148 @default.
- W1774946543 hasConceptScore W1774946543C61674017 @default.
- W1774946543 hasConceptScore W1774946543C71924100 @default.
- W1774946543 hasIssue "13" @default.
- W1774946543 hasLocation W17749465431 @default.
- W1774946543 hasLocation W17749465432 @default.
- W1774946543 hasLocation W17749465433 @default.
- W1774946543 hasLocation W17749465434 @default.
- W1774946543 hasLocation W17749465435 @default.
- W1774946543 hasLocation W17749465436 @default.
- W1774946543 hasOpenAccess W1774946543 @default.
- W1774946543 hasPrimaryLocation W17749465431 @default.
- W1774946543 hasRelatedWork W1774946543 @default.
- W1774946543 hasRelatedWork W2034994693 @default.
- W1774946543 hasRelatedWork W2395445725 @default.
- W1774946543 hasRelatedWork W2417569653 @default.
- W1774946543 hasRelatedWork W2419024515 @default.
- W1774946543 hasRelatedWork W2748952813 @default.
- W1774946543 hasRelatedWork W2899084033 @default.
- W1774946543 hasRelatedWork W2903009230 @default.
- W1774946543 hasRelatedWork W4232795863 @default.
- W1774946543 hasRelatedWork W4301508945 @default.
- W1774946543 hasVolume "15" @default.
- W1774946543 isParatext "false" @default.
- W1774946543 isRetracted "false" @default.
- W1774946543 magId "1774946543" @default.
- W1774946543 workType "article" @default.