Matches in SemOpenAlex for { <https://semopenalex.org/work/W1775005209> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W1775005209 endingPage "750" @default.
- W1775005209 startingPage "743" @default.
- W1775005209 abstract "Methods for light and electron microscopic identification and characterization of intestinal cholera antitoxin-containing cells (ACC) using peroxidase-labeled immunoreagent are described and used to study the ACC response in mice after immunizations with cholera toxin. Specific ACC appeared in significant numbers after two oral immunizations and increased six- to eightfold with two additional oral boosters, whereas further oral immunizations caused no additional stimulation. Intravenous immunizations had to be repeated seven times before ACC could be detected. After two oral immunizations, most of the ACC were found in the proximal part of the small intestine and no ACC were seen in the colon. This uneven distribution of ACC within the small intestine was eliminated after four oral immunizations, when ACC could also be detected in the colon. The ACC response after four oral immunizations demonstrated a peak at 4 days with far fewer cells present at 2 and 7 days. Electron microscopic studies showed that the ACC were mature plasma cells with the staining localized to the endoplasmic reticulum. Regression analysis of the relationship between the number of ACC and the magnitude of protective immunity against intestinal challenge with cholera toxin indicates a highly significant correlation (r = 0.91, P less than 0.001)." @default.
- W1775005209 created "2016-06-24" @default.
- W1775005209 creator A5001445711 @default.
- W1775005209 creator A5018738928 @default.
- W1775005209 creator A5091434393 @default.
- W1775005209 creator A5091566056 @default.
- W1775005209 date "1979-03-01" @default.
- W1775005209 modified "2023-10-17" @default.
- W1775005209 title "Local cholera immunity in mice: intestinal antitoxin-containing cells and their correlation with protective immunity" @default.
- W1775005209 cites W1807255898 @default.
- W1775005209 cites W1812226627 @default.
- W1775005209 cites W1932161190 @default.
- W1775005209 cites W1999626234 @default.
- W1775005209 cites W2015376750 @default.
- W1775005209 cites W2035762587 @default.
- W1775005209 cites W2047782050 @default.
- W1775005209 cites W2080726191 @default.
- W1775005209 cites W2119017497 @default.
- W1775005209 cites W2151231994 @default.
- W1775005209 cites W2161175810 @default.
- W1775005209 cites W2165675176 @default.
- W1775005209 cites W2167907759 @default.
- W1775005209 cites W2327191329 @default.
- W1775005209 cites W2330096355 @default.
- W1775005209 cites W2409780548 @default.
- W1775005209 doi "https://doi.org/10.1128/iai.23.3.743-750.1979" @default.
- W1775005209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/414229" @default.
- W1775005209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/457257" @default.
- W1775005209 hasPublicationYear "1979" @default.
- W1775005209 type Work @default.
- W1775005209 sameAs 1775005209 @default.
- W1775005209 citedByCount "26" @default.
- W1775005209 crossrefType "journal-article" @default.
- W1775005209 hasAuthorship W1775005209A5001445711 @default.
- W1775005209 hasAuthorship W1775005209A5018738928 @default.
- W1775005209 hasAuthorship W1775005209A5091434393 @default.
- W1775005209 hasAuthorship W1775005209A5091566056 @default.
- W1775005209 hasBestOaLocation W17750052091 @default.
- W1775005209 hasConcept C126322002 @default.
- W1775005209 hasConcept C134018914 @default.
- W1775005209 hasConcept C203014093 @default.
- W1775005209 hasConcept C2776280935 @default.
- W1775005209 hasConcept C2777006276 @default.
- W1775005209 hasConcept C2777047711 @default.
- W1775005209 hasConcept C2777056448 @default.
- W1775005209 hasConcept C2777367657 @default.
- W1775005209 hasConcept C2777882243 @default.
- W1775005209 hasConcept C2778643871 @default.
- W1775005209 hasConcept C2778973234 @default.
- W1775005209 hasConcept C2779341262 @default.
- W1775005209 hasConcept C2780722889 @default.
- W1775005209 hasConcept C523546767 @default.
- W1775005209 hasConcept C54355233 @default.
- W1775005209 hasConcept C55493867 @default.
- W1775005209 hasConcept C71924100 @default.
- W1775005209 hasConcept C86803240 @default.
- W1775005209 hasConcept C8891405 @default.
- W1775005209 hasConcept C89423630 @default.
- W1775005209 hasConceptScore W1775005209C126322002 @default.
- W1775005209 hasConceptScore W1775005209C134018914 @default.
- W1775005209 hasConceptScore W1775005209C203014093 @default.
- W1775005209 hasConceptScore W1775005209C2776280935 @default.
- W1775005209 hasConceptScore W1775005209C2777006276 @default.
- W1775005209 hasConceptScore W1775005209C2777047711 @default.
- W1775005209 hasConceptScore W1775005209C2777056448 @default.
- W1775005209 hasConceptScore W1775005209C2777367657 @default.
- W1775005209 hasConceptScore W1775005209C2777882243 @default.
- W1775005209 hasConceptScore W1775005209C2778643871 @default.
- W1775005209 hasConceptScore W1775005209C2778973234 @default.
- W1775005209 hasConceptScore W1775005209C2779341262 @default.
- W1775005209 hasConceptScore W1775005209C2780722889 @default.
- W1775005209 hasConceptScore W1775005209C523546767 @default.
- W1775005209 hasConceptScore W1775005209C54355233 @default.
- W1775005209 hasConceptScore W1775005209C55493867 @default.
- W1775005209 hasConceptScore W1775005209C71924100 @default.
- W1775005209 hasConceptScore W1775005209C86803240 @default.
- W1775005209 hasConceptScore W1775005209C8891405 @default.
- W1775005209 hasConceptScore W1775005209C89423630 @default.
- W1775005209 hasIssue "3" @default.
- W1775005209 hasLocation W17750052091 @default.
- W1775005209 hasLocation W17750052092 @default.
- W1775005209 hasOpenAccess W1775005209 @default.
- W1775005209 hasPrimaryLocation W17750052091 @default.
- W1775005209 hasRelatedWork W1775005209 @default.
- W1775005209 hasRelatedWork W1914790964 @default.
- W1775005209 hasRelatedWork W1975192739 @default.
- W1775005209 hasRelatedWork W2001360571 @default.
- W1775005209 hasRelatedWork W2017576079 @default.
- W1775005209 hasRelatedWork W2062211532 @default.
- W1775005209 hasRelatedWork W2113968399 @default.
- W1775005209 hasRelatedWork W2121963792 @default.
- W1775005209 hasRelatedWork W2517091567 @default.
- W1775005209 hasRelatedWork W2170475416 @default.
- W1775005209 hasVolume "23" @default.
- W1775005209 isParatext "false" @default.
- W1775005209 isRetracted "false" @default.
- W1775005209 magId "1775005209" @default.
- W1775005209 workType "article" @default.