FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1775230489> ?p ?o ?g. }

• W1775230489 endingPage "H622" @default.
• W1775230489 startingPage "H614" @default.
• W1775230489 abstract "The aim of this study was to determine whether extracellular signal-regulated kinases 1/2 (ERK1/ERK2) are activated and might play a role in enhanced proliferation and morphological change induced by strain. Bovine aortic endothelial cells (BAEC) were subjected to an average of 6 or 10% strain at a rate of 60 cycles/min for up to 4 h. Cyclic strain caused strain- and time-dependent phosphorylation and activation of ERK1/ERK2. Peak phosphorylation and activation of ERK1/ERK2 induced by 10% strain were at 10 min. A specific ERK1/ERK2 kinase inhibitor, PD-98059, inhibited phosphorylation and activation of ERK1/ERK2 but did not inhibit the increased cell proliferation and cell alignment induced by strain. Treatment of BAEC with 2,5-di- tert-butyl-1,4-benzohydroquinone, to deplete inositol trisphosphate-sensitive calcium storage, and gadolinium chloride, a Ca 2+ channel blocker, did not inhibit the activation of ERK1/ERK2. Strain-induced ERK1/ERK2 activation was partly inhibited by the protein kinase C inhibitor calphostin C and completely inhibited by the tyrosine kinase inhibitor genistein. These data suggest that 1) ERK1/ERK2 are not critically involved in the strain-induced cell proliferation and orientation, 2) strain-dependent activation of ERK1/ERK2 is independent of intracellular and extracellular calcium mobilization, and 3) protein kinase C activation and tyrosine kinase regulate strain-induced activation of ERK1/ERK2." @default.
• W1775230489 created "2016-06-24" @default.
• W1775230489 creator A5003753800 @default.
• W1775230489 creator A5056531353 @default.
• W1775230489 creator A5062092620 @default.
• W1775230489 creator A5070404643 @default.
• W1775230489 creator A5072838139 @default.
• W1775230489 date "1999-02-01" @default.
• W1775230489 modified "2023-10-10" @default.
• W1775230489 title "Extracellular signal-regulated kinases 1 and 2 activation in endothelial cells exposed to cyclic strain" @default.
• W1775230489 cites W139123032 @default.
• W1775230489 cites W1537459781 @default.
• W1775230489 cites W1542412714 @default.
• W1775230489 cites W1565303318 @default.
• W1775230489 cites W1573821584 @default.
• W1775230489 cites W1971915141 @default.
• W1775230489 cites W1975853356 @default.
• W1775230489 cites W1977677084 @default.
• W1775230489 cites W1981462495 @default.
• W1775230489 cites W1994651714 @default.
• W1775230489 cites W1996570657 @default.
• W1775230489 cites W1999083451 @default.
• W1775230489 cites W2006184287 @default.
• W1775230489 cites W2007417655 @default.
• W1775230489 cites W2052682734 @default.
• W1775230489 cites W2062104829 @default.
• W1775230489 cites W2067592908 @default.
• W1775230489 cites W2068502127 @default.
• W1775230489 cites W2068913584 @default.
• W1775230489 cites W2069258214 @default.
• W1775230489 cites W2069846805 @default.
• W1775230489 cites W2075473225 @default.
• W1775230489 cites W2077233283 @default.
• W1775230489 cites W2079051863 @default.
• W1775230489 cites W2084017530 @default.
• W1775230489 cites W2085514543 @default.
• W1775230489 cites W2086275741 @default.
• W1775230489 cites W2087388405 @default.
• W1775230489 cites W2100837269 @default.
• W1775230489 cites W2101108802 @default.
• W1775230489 cites W2104238956 @default.
• W1775230489 cites W2115469333 @default.
• W1775230489 cites W2117774225 @default.
• W1775230489 cites W2121700889 @default.
• W1775230489 cites W2130870274 @default.
• W1775230489 cites W2138231208 @default.
• W1775230489 cites W2141518234 @default.
• W1775230489 cites W2143873872 @default.
• W1775230489 cites W2152343301 @default.
• W1775230489 cites W2158592093 @default.
• W1775230489 cites W2231219683 @default.
• W1775230489 cites W2411702708 @default.
• W1775230489 cites W2414392119 @default.
• W1775230489 cites W2425562753 @default.
• W1775230489 cites W4293247451 @default.
• W1775230489 doi "https://doi.org/10.1152/ajpheart.1999.276.2.h614" @default.
• W1775230489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9950863" @default.
• W1775230489 hasPublicationYear "1999" @default.
• W1775230489 type Work @default.
• W1775230489 sameAs 1775230489 @default.
• W1775230489 citedByCount "28" @default.
• W1775230489 countsByYear W17752304892014 @default.
• W1775230489 countsByYear W17752304892015 @default.
• W1775230489 countsByYear W17752304892016 @default.
• W1775230489 countsByYear W17752304892017 @default.
• W1775230489 crossrefType "journal-article" @default.
• W1775230489 hasAuthorship W1775230489A5003753800 @default.
• W1775230489 hasAuthorship W1775230489A5056531353 @default.
• W1775230489 hasAuthorship W1775230489A5062092620 @default.
• W1775230489 hasAuthorship W1775230489A5070404643 @default.
• W1775230489 hasAuthorship W1775230489A5072838139 @default.
• W1775230489 hasConcept C11960822 @default.
• W1775230489 hasConcept C132149769 @default.
• W1775230489 hasConcept C153911025 @default.
• W1775230489 hasConcept C184235292 @default.
• W1775230489 hasConcept C185592680 @default.
• W1775230489 hasConcept C2780245509 @default.
• W1775230489 hasConcept C2781168148 @default.
• W1775230489 hasConcept C28406088 @default.
• W1775230489 hasConcept C86803240 @default.
• W1775230489 hasConcept C95444343 @default.
• W1775230489 hasConcept C97029542 @default.
• W1775230489 hasConceptScore W1775230489C11960822 @default.
• W1775230489 hasConceptScore W1775230489C132149769 @default.
• W1775230489 hasConceptScore W1775230489C153911025 @default.
• W1775230489 hasConceptScore W1775230489C184235292 @default.
• W1775230489 hasConceptScore W1775230489C185592680 @default.
• W1775230489 hasConceptScore W1775230489C2780245509 @default.
• W1775230489 hasConceptScore W1775230489C2781168148 @default.
• W1775230489 hasConceptScore W1775230489C28406088 @default.
• W1775230489 hasConceptScore W1775230489C86803240 @default.
• W1775230489 hasConceptScore W1775230489C95444343 @default.
• W1775230489 hasConceptScore W1775230489C97029542 @default.
• W1775230489 hasIssue "2" @default.
• W1775230489 hasLocation W17752304891 @default.
• W1775230489 hasLocation W17752304892 @default.
• W1775230489 hasOpenAccess W1775230489 @default.
• W1775230489 hasPrimaryLocation W17752304891 @default.

• next