FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1775354871> ?p ?o ?g. }

• W1775354871 endingPage "345" @default.
• W1775354871 startingPage "339" @default.
• W1775354871 abstract "Background The p38 mitogen‐activated protein kinase (MAPK) plays an important role in inflammatory processes and displays increased activity in psoriasis. Dual‐specificity phosphatase 1 (DUSP1) is an important negative regulator of p38 MAPK activity. Objectives To study mRNA expression of DUSP1 in normal human epidermal keratinocytes (NHEKs) stimulated with proinflammatory cytokines and to investigate DUSP1 in psoriatic skin. Methods NHEKs were cultured in vitro and punch biopsies were obtained from the skin of patients with psoriasis vulgaris and atopic dermatitis. mRNA expression was analysed by reverse transcription–quantitative polymerase chain reaction (RT‐qPCR). Results In NHEKs, interleukin (IL)‐1β induced DUSP1 mRNA expression in a rapid and time‐dependent manner through the p38 MAPK/mitogen‐ and stress‐activated kinase (MSK) signalling pathway. DUSP1 mRNA expression was demonstrated to be significantly downregulated in psoriatic skin lesions compared with paired samples of nonlesional psoriatic skin. This was in contrast to atopic dermatitis. The downregulation of DUSP1 mRNA in lesional psoriatic skin was not explained by the difference in the mRNA expression of the potential DUSP1 transcript stability‐affecting proteins Hu antigen R or tristetraprolin. Furthermore, DUSP1 mRNA expression was shown not to increase during the early course of treatment with the antitumour necrosis factor‐α antibody adalimumab. Conclusions In lesional psoriatic skin, the p38 MAPK negative feedback mechanism provided by DUSP1 seems to be inhibited. Downregulation of DUSP1 may contribute to the sustained inflammatory response seen in psoriasis." @default.
• W1775354871 created "2016-06-24" @default.
• W1775354871 creator A5020564267 @default.
• W1775354871 creator A5035700990 @default.
• W1775354871 creator A5067975004 @default.
• W1775354871 creator A5068079740 @default.
• W1775354871 date "2013-01-30" @default.
• W1775354871 modified "2023-09-27" @default.
• W1775354871 title "The expression of dual-specificity phosphatase 1 mRNA is downregulated in lesional psoriatic skin" @default.
• W1775354871 cites W1569578194 @default.
• W1775354871 cites W1594962297 @default.
• W1775354871 cites W1607933978 @default.
• W1775354871 cites W178098991 @default.
• W1775354871 cites W1902683402 @default.
• W1775354871 cites W1965591217 @default.
• W1775354871 cites W1971925780 @default.
• W1775354871 cites W1983587675 @default.
• W1775354871 cites W1984230217 @default.
• W1775354871 cites W1991281300 @default.
• W1775354871 cites W1993170284 @default.
• W1775354871 cites W1995246332 @default.
• W1775354871 cites W2011245371 @default.
• W1775354871 cites W2012585552 @default.
• W1775354871 cites W2014859793 @default.
• W1775354871 cites W2019678378 @default.
• W1775354871 cites W2031794136 @default.
• W1775354871 cites W2041769117 @default.
• W1775354871 cites W2047152276 @default.
• W1775354871 cites W2050524172 @default.
• W1775354871 cites W2052750950 @default.
• W1775354871 cites W2062390081 @default.
• W1775354871 cites W2072307972 @default.
• W1775354871 cites W2073507583 @default.
• W1775354871 cites W2074328584 @default.
• W1775354871 cites W2077768378 @default.
• W1775354871 cites W2079585730 @default.
• W1775354871 cites W2088016221 @default.
• W1775354871 cites W2098791327 @default.
• W1775354871 cites W2102606027 @default.
• W1775354871 cites W2108811975 @default.
• W1775354871 cites W2110657360 @default.
• W1775354871 cites W2122057254 @default.
• W1775354871 cites W2124000892 @default.
• W1775354871 cites W2125088870 @default.
• W1775354871 cites W2135086805 @default.
• W1775354871 cites W2138138193 @default.
• W1775354871 cites W2138718238 @default.
• W1775354871 cites W2153307836 @default.
• W1775354871 cites W2160835410 @default.
• W1775354871 cites W4237627879 @default.
• W1775354871 doi "https://doi.org/10.1111/bjd.12020" @default.
• W1775354871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22924482" @default.
• W1775354871 hasPublicationYear "2013" @default.
• W1775354871 type Work @default.
• W1775354871 sameAs 1775354871 @default.
• W1775354871 citedByCount "14" @default.
• W1775354871 countsByYear W17753548712013 @default.
• W1775354871 countsByYear W17753548712014 @default.
• W1775354871 countsByYear W17753548712017 @default.
• W1775354871 countsByYear W17753548712018 @default.
• W1775354871 countsByYear W17753548712019 @default.
• W1775354871 countsByYear W17753548712020 @default.
• W1775354871 countsByYear W17753548712022 @default.
• W1775354871 countsByYear W17753548712023 @default.
• W1775354871 crossrefType "journal-article" @default.
• W1775354871 hasAuthorship W1775354871A5020564267 @default.
• W1775354871 hasAuthorship W1775354871A5035700990 @default.
• W1775354871 hasAuthorship W1775354871A5067975004 @default.
• W1775354871 hasAuthorship W1775354871A5068079740 @default.
• W1775354871 hasConcept C104317684 @default.
• W1775354871 hasConcept C105580179 @default.
• W1775354871 hasConcept C11960822 @default.
• W1775354871 hasConcept C127561419 @default.
• W1775354871 hasConcept C153911025 @default.
• W1775354871 hasConcept C164027704 @default.
• W1775354871 hasConcept C178666793 @default.
• W1775354871 hasConcept C17991360 @default.
• W1775354871 hasConcept C184235292 @default.
• W1775354871 hasConcept C203014093 @default.
• W1775354871 hasConcept C2776914184 @default.
• W1775354871 hasConcept C2780564577 @default.
• W1775354871 hasConcept C502942594 @default.
• W1775354871 hasConcept C51551487 @default.
• W1775354871 hasConcept C55493867 @default.
• W1775354871 hasConcept C57074206 @default.
• W1775354871 hasConcept C71924100 @default.
• W1775354871 hasConcept C86803240 @default.
• W1775354871 hasConcept C95444343 @default.
• W1775354871 hasConcept C97029542 @default.
• W1775354871 hasConceptScore W1775354871C104317684 @default.
• W1775354871 hasConceptScore W1775354871C105580179 @default.
• W1775354871 hasConceptScore W1775354871C11960822 @default.
• W1775354871 hasConceptScore W1775354871C127561419 @default.
• W1775354871 hasConceptScore W1775354871C153911025 @default.
• W1775354871 hasConceptScore W1775354871C164027704 @default.
• W1775354871 hasConceptScore W1775354871C178666793 @default.
• W1775354871 hasConceptScore W1775354871C17991360 @default.
• W1775354871 hasConceptScore W1775354871C184235292 @default.

• next