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- W1775552485 abstract "This report demonstrates the ability of folic acid to activate rat liver porphobilinogen-deaminase (PBG -D). Lineweaver-Burk analysis revealed an increase in V max (38%) without affecting the K m . In the concentration range assayed, secondary replots of 1/Δslope and 1/Δintersect versus 1/[folic acid] yielded straight lines, indicating the binding of a single molecule of activator to the enzyme PBG-D , with a K A = 1.66 mᴍ. Results presented here show that folic acid acts as a non-essential activator (α = 1; β = 1.6). The activating effect of folic acid has been observed employing the 35-70% ammonium sulphate precipitated fraction, desalted by dialysis or gel filtration, whereas no action was detected when other partially purified PBG -D preparations were utilized as the enzyme source, suggesting either the presence of sites saturated for the activator, or the existence of a different structural protein conformation, or both." @default.
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- W1775552485 date "1992-06-01" @default.
- W1775552485 modified "2023-10-17" @default.
- W1775552485 title "Non-Essential Activation of Rat Liver Porphobilinogen-Deaminase by Folic Acid" @default.
- W1775552485 doi "https://doi.org/10.1515/znc-1992-0616" @default.
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