Matches in SemOpenAlex for { <https://semopenalex.org/work/W1775609935> ?p ?o ?g. }
- W1775609935 endingPage "18" @default.
- W1775609935 startingPage "2209" @default.
- W1775609935 abstract "Patients with newly diagnosed gliomas were treated with adoptive transfer of ex vivo activated T lymphocytes, derived from lymph nodes (LNs) draining autologous tumor vaccines, to determine the long-term toxicity of this treatment. Twelve consecutive patients were enrolled: 2 with grade II astrocytoma, 4 with anaplastic gliomas, and 6 with glioblastoma multiforme. Patients were injected intradermally with short-term cultured autologous irradiated tumor cells, admixed with granulocyte macrophage colony-stimulating factor, to stimulate draining LNs. The LN cells were activated with staphylococcal enterotoxin A for 48 h and then cultured in medium containing interleukin 2 for an additional 6-8 days and subsequently transferred i.v. to the patients. The number of cells obtained from the LNs ranged from 9 x 10(7) to 1.1 x 10(9), and the median cell proliferation was 41-fold. The dose of T cells infused ranged from 0.6 to 5.5 x 10(10) with a median of 1.1 x 10(10), the majority of which were CD 4+ (mean, 71%). The entire treatment was performed as outpatient therapy and was associated with a toxicity of grade 2 or less, consisting mainly of fever, nausea, and myalgias during the first 24 h. There were no indications of late adverse events from this treatment even among three patients with follow-up greater than 2 years post T cell transfer. Moreover, four patients demonstrated partial regression of residual tumor. This Phase I clinical trial of adoptive immunotherapy for patients with newly diagnosed malignant gliomas demonstrates feasibility, lack of long-term toxicity, and several objective clinical responses." @default.
- W1775609935 created "2016-06-24" @default.
- W1775609935 creator A5014713398 @default.
- W1775609935 creator A5016811839 @default.
- W1775609935 creator A5042603807 @default.
- W1775609935 creator A5043956032 @default.
- W1775609935 creator A5050488407 @default.
- W1775609935 creator A5065213314 @default.
- W1775609935 creator A5065263618 @default.
- W1775609935 creator A5070518247 @default.
- W1775609935 date "2000-06-01" @default.
- W1775609935 modified "2023-09-24" @default.
- W1775609935 title "T cell adoptive immunotherapy of newly diagnosed gliomas." @default.
- W1775609935 cites W1444462873 @default.
- W1775609935 cites W1498976410 @default.
- W1775609935 cites W1521600055 @default.
- W1775609935 cites W1524531954 @default.
- W1775609935 cites W1547134586 @default.
- W1775609935 cites W1555981383 @default.
- W1775609935 cites W1588713113 @default.
- W1775609935 cites W1610398404 @default.
- W1775609935 cites W1610624614 @default.
- W1775609935 cites W1672419507 @default.
- W1775609935 cites W1867597158 @default.
- W1775609935 cites W1899505024 @default.
- W1775609935 cites W1910627518 @default.
- W1775609935 cites W1912294530 @default.
- W1775609935 cites W1959014364 @default.
- W1775609935 cites W1966023886 @default.
- W1775609935 cites W1969482311 @default.
- W1775609935 cites W1983205909 @default.
- W1775609935 cites W1983806918 @default.
- W1775609935 cites W2001493754 @default.
- W1775609935 cites W2011913856 @default.
- W1775609935 cites W2012910015 @default.
- W1775609935 cites W2013878898 @default.
- W1775609935 cites W2017425912 @default.
- W1775609935 cites W2032090704 @default.
- W1775609935 cites W2032897437 @default.
- W1775609935 cites W2036560693 @default.
- W1775609935 cites W2054384257 @default.
- W1775609935 cites W2059483129 @default.
- W1775609935 cites W2063495860 @default.
- W1775609935 cites W2066964346 @default.
- W1775609935 cites W2069632240 @default.
- W1775609935 cites W2070201923 @default.
- W1775609935 cites W2084511332 @default.
- W1775609935 cites W2086417745 @default.
- W1775609935 cites W2113012900 @default.
- W1775609935 cites W2122226469 @default.
- W1775609935 cites W2142198956 @default.
- W1775609935 cites W2149912943 @default.
- W1775609935 cites W2157905092 @default.
- W1775609935 cites W2159076080 @default.
- W1775609935 cites W2163342290 @default.
- W1775609935 cites W2164486810 @default.
- W1775609935 cites W2168400876 @default.
- W1775609935 cites W2263690628 @default.
- W1775609935 cites W2314979849 @default.
- W1775609935 cites W2325631775 @default.
- W1775609935 cites W2398843107 @default.
- W1775609935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10873070" @default.
- W1775609935 hasPublicationYear "2000" @default.
- W1775609935 type Work @default.
- W1775609935 sameAs 1775609935 @default.
- W1775609935 citedByCount "46" @default.
- W1775609935 countsByYear W17756099352012 @default.
- W1775609935 countsByYear W17756099352013 @default.
- W1775609935 countsByYear W17756099352014 @default.
- W1775609935 countsByYear W17756099352015 @default.
- W1775609935 countsByYear W17756099352016 @default.
- W1775609935 countsByYear W17756099352017 @default.
- W1775609935 countsByYear W17756099352018 @default.
- W1775609935 countsByYear W17756099352020 @default.
- W1775609935 countsByYear W17756099352023 @default.
- W1775609935 crossrefType "journal-article" @default.
- W1775609935 hasAuthorship W1775609935A5014713398 @default.
- W1775609935 hasAuthorship W1775609935A5016811839 @default.
- W1775609935 hasAuthorship W1775609935A5042603807 @default.
- W1775609935 hasAuthorship W1775609935A5043956032 @default.
- W1775609935 hasAuthorship W1775609935A5050488407 @default.
- W1775609935 hasAuthorship W1775609935A5065213314 @default.
- W1775609935 hasAuthorship W1775609935A5065263618 @default.
- W1775609935 hasAuthorship W1775609935A5070518247 @default.
- W1775609935 hasConcept C121608353 @default.
- W1775609935 hasConcept C126322002 @default.
- W1775609935 hasConcept C142724271 @default.
- W1775609935 hasConcept C143998085 @default.
- W1775609935 hasConcept C203014093 @default.
- W1775609935 hasConcept C2776090121 @default.
- W1775609935 hasConcept C2777371288 @default.
- W1775609935 hasConcept C2777701055 @default.
- W1775609935 hasConcept C2778227246 @default.
- W1775609935 hasConcept C2778690821 @default.
- W1775609935 hasConcept C2778880634 @default.
- W1775609935 hasConcept C2779083369 @default.
- W1775609935 hasConcept C2779720271 @default.
- W1775609935 hasConcept C2908885563 @default.