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- W1775729004 abstract "Publisher Summary This chapter discusses the clinical studies done with the peptides related to adrenocorticotrophic hormone (ACTH) and vasopressin. The chapter discusses the several factors that hamper a clearcut statement on whether there is a positive effect of these substances. The chapter focuses on these two factors, first, the heterogeneity of memory disorders and the differences in the cerebral substrates that underlie the different aspects of memory, and second, the nature of the test and observation methods that are used for diagnosis and treatment evaluation. Therefore, an overview is given with respect to the most important aspects of these issues, before describing the animal and clinical studies with ACTH-like peptides and vasopressin. The amount of vasopressin that can be used in humans is limited, because of peripheral side effects, while high doses are necessary to enable sufficient vasopressin to pass the blood-brain barrier and reach the central nervous system." @default.
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- W1775729004 date "1986-01-01" @default.
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- W1775729004 title "Neuropeptides and Cognitive Disorders" @default.
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- W1775729004 doi "https://doi.org/10.1016/s0079-6123(08)60650-0" @default.
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