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• W1775761483 endingPage "7755" @default.
• W1775761483 startingPage "7747" @default.
• W1775761483 abstract "Abstract Although the requirements for T lymphocyte homing to lymph nodes (LNs) are well studied, much less is known about the requirements for T lymphocyte locomotion within LNs. Imaging of murine T lymphocyte migration in explanted LNs using two-photon laser-scanning fluorescence microscopy provides an opportunity to systematically study these requirements. We have developed a closed system for imaging an intact LN with controlled temperature, oxygenation, and perfusion rate. Naive T lymphocyte locomotion in the deep paracortex of the LN required a perfusion rate of &gt;13 μm/s and a partial pressure of O2 (pO2) of &gt;7.4%. Naive T lymphocyte locomotion in the subcapsular region was 38% slower and had higher turning angles and arrest coefficients than naive T lymphocytes in the deep paracortex. T lymphocyte activation decreased the requirement for pO2, but also decreased the speed of locomotion in the deep paracortex. Although CCR7−/− naive T cells displayed a small reduction in locomotion, systemic treatment with pertussis toxin reduced naive T lymphocyte speed by 59%, indicating a contribution of Gαi-mediated signaling, but involvement of other G protein-coupled receptors besides CCR7. Receptor knockouts or pharmacological inhibition in the adenosine, PG/lipoxygenase, lysophosphatidylcholine, and sphingosine-1-phosphate pathways did not individually alter naive T cell migration. These data implicate pO2, tissue architecture, and G-protein coupled receptor signaling in regulation of naive T lymphocyte migration in explanted LNs." @default.
• W1775761483 created "2016-06-24" @default.
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• W1775761483 date "2007-06-15" @default.
• W1775761483 modified "2023-10-17" @default.
• W1775761483 title "Requirements for T Lymphocyte Migration in Explanted Lymph Nodes" @default.
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• W1775761483 doi "https://doi.org/10.4049/jimmunol.178.12.7747" @default.
• W1775761483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17548612" @default.
• W1775761483 hasPublicationYear "2007" @default.
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