Matches in SemOpenAlex for { <https://semopenalex.org/work/W177603265> ?p ?o ?g. }
- W177603265 endingPage "20" @default.
- W177603265 startingPage "1" @default.
- W177603265 abstract "High mobility group box 1 (HMGB1), an evolutionarily highly conserved and abundant nuclear protein also has roles within the cytoplasm and as an extracellular damage-associated molecular pattern (DAMP) molecule. Extracellular HMGB1 is the prototypic endogenous 'danger signal' that triggers inflammation and immunity. Recent findings suggest that posttranslational modifications dictate the cellular localization and secretion of HMGB1. HMGB1 is actively secreted from immune cells and stressed cancer cells, or passively released from necrotic cells. During cancer development or administration of therapeutic agents including chemotherapy, radiation, epigenetic drugs, oncolytic viruses, or immunotherapy, the released HMGB1 may either promote or limit cancer growth, depending on the state of progression and vascularization of the tumor. Extracellular HMGB1 enhances autophagy and promotes persistence of surviving cancer cells following initial activation. When oxidized, it chronically suppresses the immune system to promote cancer growth and progression, thereby enhancing resistance to cancer therapeutics. In its reduced form, it can facilitate and elicit innate and adaptive anti-tumor immunity, recruiting and activating immune cells, in conjunction with cytotoxic agents, particularly in early transplantable tumor models. We hypothesize that HMGB1 also functions as an epigenetic modifier, mainly through regulation of NF-kB-dependent signaling pathways, to modulate the behavior of surviving cancer cells as well as the immune cells found within the tumor microenvironment. This has significant implications for developing novel cancer therapeutics." @default.
- W177603265 created "2016-06-24" @default.
- W177603265 creator A5007616348 @default.
- W177603265 creator A5024528047 @default.
- W177603265 creator A5026230747 @default.
- W177603265 creator A5039127454 @default.
- W177603265 creator A5051030840 @default.
- W177603265 date "2013-01-01" @default.
- W177603265 modified "2023-10-02" @default.
- W177603265 title "Life after death: targeting high mobility group box 1 in emergent cancer therapies." @default.
- W177603265 cites W1244763136 @default.
- W177603265 cites W1486665165 @default.
- W177603265 cites W1504155896 @default.
- W177603265 cites W1513303790 @default.
- W177603265 cites W1517513312 @default.
- W177603265 cites W1517971401 @default.
- W177603265 cites W1541957757 @default.
- W177603265 cites W1542062417 @default.
- W177603265 cites W1550121053 @default.
- W177603265 cites W161484625 @default.
- W177603265 cites W1672954108 @default.
- W177603265 cites W1837125915 @default.
- W177603265 cites W1902173561 @default.
- W177603265 cites W1910578170 @default.
- W177603265 cites W1934726430 @default.
- W177603265 cites W1935354242 @default.
- W177603265 cites W1965820060 @default.
- W177603265 cites W1966591852 @default.
- W177603265 cites W1967393044 @default.
- W177603265 cites W1967504120 @default.
- W177603265 cites W1968375883 @default.
- W177603265 cites W1969305254 @default.
- W177603265 cites W1971902328 @default.
- W177603265 cites W1972204333 @default.
- W177603265 cites W1972241916 @default.
- W177603265 cites W1980654946 @default.
- W177603265 cites W1981311979 @default.
- W177603265 cites W1982502197 @default.
- W177603265 cites W1982935125 @default.
- W177603265 cites W1984270065 @default.
- W177603265 cites W1984848481 @default.
- W177603265 cites W1986912320 @default.
- W177603265 cites W1990803471 @default.
- W177603265 cites W1992082488 @default.
- W177603265 cites W1994120609 @default.
- W177603265 cites W1994823455 @default.
- W177603265 cites W1995177733 @default.
- W177603265 cites W1997108294 @default.
- W177603265 cites W1998103032 @default.
- W177603265 cites W1999998145 @default.
- W177603265 cites W2004100752 @default.
- W177603265 cites W2004266769 @default.
- W177603265 cites W2005640704 @default.
- W177603265 cites W2006201075 @default.
- W177603265 cites W2008033547 @default.
- W177603265 cites W2010645034 @default.
- W177603265 cites W2012053447 @default.
- W177603265 cites W2014758051 @default.
- W177603265 cites W2016000295 @default.
- W177603265 cites W2018653121 @default.
- W177603265 cites W2018905044 @default.
- W177603265 cites W2019773562 @default.
- W177603265 cites W2020323703 @default.
- W177603265 cites W2021863432 @default.
- W177603265 cites W2022798707 @default.
- W177603265 cites W2023561138 @default.
- W177603265 cites W2023688724 @default.
- W177603265 cites W2024063880 @default.
- W177603265 cites W2024715765 @default.
- W177603265 cites W2025575974 @default.
- W177603265 cites W2029055826 @default.
- W177603265 cites W2029068688 @default.
- W177603265 cites W2029773447 @default.
- W177603265 cites W2031046732 @default.
- W177603265 cites W2033106764 @default.
- W177603265 cites W2034159685 @default.
- W177603265 cites W2036702562 @default.
- W177603265 cites W2040259875 @default.
- W177603265 cites W2040861398 @default.
- W177603265 cites W2042939195 @default.
- W177603265 cites W2044737524 @default.
- W177603265 cites W2045316920 @default.
- W177603265 cites W2045485630 @default.
- W177603265 cites W2045765219 @default.
- W177603265 cites W2046290067 @default.
- W177603265 cites W2052094075 @default.
- W177603265 cites W2054344840 @default.
- W177603265 cites W2054348877 @default.
- W177603265 cites W2056475500 @default.
- W177603265 cites W2059718338 @default.
- W177603265 cites W2062927905 @default.
- W177603265 cites W2065986242 @default.
- W177603265 cites W2067632426 @default.
- W177603265 cites W2067692987 @default.
- W177603265 cites W2067914895 @default.
- W177603265 cites W2074098407 @default.
- W177603265 cites W2077382378 @default.
- W177603265 cites W2078899581 @default.