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• W1776133500 abstract "ObjectiveTo identify circulating tumor cells (CTCs) in the blood of patients with early-stage lung cancer and to show that sampling pulmonary vein (PV) blood using microfluidic chip technology will yield significantly more CTCs. Improving early detection of lung cancer is critical to improving lung cancer survival. Reproducible detection of CTCs is limited currently in early stage tumors.MethodsPatients undergoing pulmonary resection had PV blood drawn before resection. Peripheral blood was sampled at preoperative, intraoperative, and postoperative times. Samples were analyzed on microfluidic chips using antibody-based capture.ResultsA total of 32 patients with primary lung cancer were evaluated. Twenty patients had 1 or more CTCs detected in at least 1 sample (62.5%). The mean number of CTCs from peripheral vein sources at the preoperative, intraoperative, and postoperative time points was 1.3, 1.9, and 0.6 respectively. The average number of CTCs in the PV was 340.0 (range, 0.0-5422.50; P > .01). When PV CTCs were present, the number of CTCs was correlated with pathological tumor size (P = .0236). The number of PV CTCs was not correlated with any other clinical feature (eg, smoking status, preoperative or postoperative stage). Furthermore, the number of PV CTCs was significantly higher when preoperative bronchoscopic biopsy was performed, compared with computed tomography–guided biopsy (P = .0311). Seven patients had evidence of CTC clusters, or microemboli.ConclusionsWith a single vein draining the entire tumor basin, lung cancers are unique, allowing the high-yield isolation of CTCs from the PV. This method may facilitate future studies to improve the detection and analysis of early-stage lung CTCs." @default.
• W1776133500 created "2016-06-24" @default.
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• W1776133500 date "2016-03-01" @default.
• W1776133500 modified "2023-09-26" @default.
• W1776133500 title "Pulmonary venous blood sampling significantly increases the yield of circulating tumor cells in early-stage lung cancer" @default.
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• W1776133500 doi "https://doi.org/10.1016/j.jtcvs.2015.09.126" @default.
• W1776133500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26614417" @default.
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