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- W1776136554 abstract "The fibrinolytic system is responsible for the proteolytic degradation of fibrin and therefore plays a role in haemostasis and thrombosis. Intravascular thrombosis, a consequence of fibrin aggregation in the arteries, is one of the main causes of cardiovascular disease. Fibrin is the primary protein component of blood clots, which are formed from fibrinogen by thrombin. Formation of fibrin clot and fibrinolysis are normally well balanced in biological systems. However, if fibrin is not hydrolyzed due to some disorder, thrombosis can occur. The most common consequence of such thrombosis is myocardial infarction. Fibrinolytic enzymes are agents which dissolve fibrin clot. Today available agents are mostly plasminogen activator (t-PA), urokinase and streptokinase, which exhibit low specificity for fibrin, have undesired side effect and are also relatively expensive. Therefore, the search for other fibrinolytic agent from various sources continues. The presence of fibrinolytic activity in ceolomic fluid or tissue homogenate from earthworm has been reported previously. Because of that, earthworm tissue homogenate is an attractive source of various physiologically active compounds. _____________________________________________________________________________________________________________" @default.
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- W1776136554 date "2009-01-01" @default.
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- W1776136554 title "Fibrinolytic enzymes from earthworms." @default.
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