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- W1776172174 abstract "Individuals with Down syndrome have an enhanced risk of developing early onset Alzheimer disease. Here, the authors describe the features of Alzheimer disease in Down syndrome and show how understanding the genetic and pathogenic mechanisms of this form of Alzheimer disease may shed light on more general mechanisms of neurodegeneration. Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP) — an Alzheimer disease risk factor — although the possession of extra copies of other chromosome 21 genes may also play a part. Further study of the mechanisms underlying the development of Alzheimer disease in people with Down syndrome could provide insights into the mechanisms that cause dementia in the general population." @default.
- W1776172174 created "2016-06-24" @default.
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- W1776172174 date "2015-08-05" @default.
- W1776172174 modified "2023-10-11" @default.
- W1776172174 title "A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome" @default.
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