Matches in SemOpenAlex for { <https://semopenalex.org/work/W177621860> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W177621860 endingPage "7278" @default.
- W177621860 startingPage "7273" @default.
- W177621860 abstract "The role of vacuolar Ca2+ transport systems in regulating cellular Ca2+ was investigated by measuring the vacuolar Ca2+ transport rate, the free energy available to drive vacuolar Ca2+ transport, the ability of the vacuole to buffer lumenal Ca2+, and the vacuolar Ca2+ efflux rate. The magnitude of the Ca2+ gradient generated by the vacuolar H+ gradient best supports a 1 Ca2+:2 H+ coupling ratio for the vacuolar Ca2+/H+ exchanger. This coupling ratio along with a cytosolic Ca2+ concentration of 125 nM would give a vacuolar free Ca2+ concentration of approximately 30 microM. The total vacuolar Ca2+ concentration is approximately 2 mM due to Ca2+ binding to vacuolar polyphosphate. The Ca2+ efflux rate from the vacuole is less than the growth rate indicating that the steady-state Ca2+ loading level of the vacuole is dependent mainly on the Ca2+ transport rate and the rate that vacuolar Ca2+ is diluted by growth. Based on the kinetic parameters of vacuolar Ca2+ accumulation in vitro, the maximum rate of Ca2+ accumulation in vivo is expected to be approximately 0.2 nmol of Ca2+ min-1 mg protein-1, a rate that is similar to the cellular Ca2+ accumulation rate. The cytosolic Ca2+ concentration increases from 0.1 microM to 1-2 microM as the extracellular Ca2+ concentration is raised from 0.3 mM to 50 mM. The rise in cytosolic Ca2+ concentration increases cellular Ca2+ from 10 to 300 nmol Ca2+/mg by increasing the rate of vacuolar Ca2+ accumulation but does not significantly alter the cellular growth rate." @default.
- W177621860 created "2016-06-24" @default.
- W177621860 creator A5020758801 @default.
- W177621860 creator A5037446902 @default.
- W177621860 creator A5063910997 @default.
- W177621860 date "1994-03-01" @default.
- W177621860 modified "2023-10-03" @default.
- W177621860 title "Regulation of cellular Ca2+ by yeast vacuoles." @default.
- W177621860 cites W1488647821 @default.
- W177621860 cites W1497289365 @default.
- W177621860 cites W1513016594 @default.
- W177621860 cites W1519338837 @default.
- W177621860 cites W1532622259 @default.
- W177621860 cites W1535401962 @default.
- W177621860 cites W1546910338 @default.
- W177621860 cites W1592537807 @default.
- W177621860 cites W1647306826 @default.
- W177621860 cites W1872374211 @default.
- W177621860 cites W1912410317 @default.
- W177621860 cites W1967897161 @default.
- W177621860 cites W2020524491 @default.
- W177621860 cites W2022414499 @default.
- W177621860 cites W2044115537 @default.
- W177621860 cites W2050214403 @default.
- W177621860 cites W2054182604 @default.
- W177621860 cites W2061962822 @default.
- W177621860 cites W2068559629 @default.
- W177621860 cites W2093695208 @default.
- W177621860 cites W2095111890 @default.
- W177621860 cites W2101195413 @default.
- W177621860 cites W2125855207 @default.
- W177621860 cites W4240065971 @default.
- W177621860 doi "https://doi.org/10.1016/s0021-9258(17)37279-4" @default.
- W177621860 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8125940" @default.
- W177621860 hasPublicationYear "1994" @default.
- W177621860 type Work @default.
- W177621860 sameAs 177621860 @default.
- W177621860 citedByCount "170" @default.
- W177621860 countsByYear W1776218602012 @default.
- W177621860 countsByYear W1776218602013 @default.
- W177621860 countsByYear W1776218602014 @default.
- W177621860 countsByYear W1776218602015 @default.
- W177621860 countsByYear W1776218602016 @default.
- W177621860 countsByYear W1776218602017 @default.
- W177621860 countsByYear W1776218602018 @default.
- W177621860 countsByYear W1776218602019 @default.
- W177621860 countsByYear W1776218602020 @default.
- W177621860 countsByYear W1776218602021 @default.
- W177621860 countsByYear W1776218602022 @default.
- W177621860 countsByYear W1776218602023 @default.
- W177621860 crossrefType "journal-article" @default.
- W177621860 hasAuthorship W177621860A5020758801 @default.
- W177621860 hasAuthorship W177621860A5037446902 @default.
- W177621860 hasAuthorship W177621860A5063910997 @default.
- W177621860 hasBestOaLocation W1776218601 @default.
- W177621860 hasConcept C102568950 @default.
- W177621860 hasConcept C185592680 @default.
- W177621860 hasConcept C190062978 @default.
- W177621860 hasConcept C2779222958 @default.
- W177621860 hasConcept C55493867 @default.
- W177621860 hasConcept C86803240 @default.
- W177621860 hasConcept C95444343 @default.
- W177621860 hasConceptScore W177621860C102568950 @default.
- W177621860 hasConceptScore W177621860C185592680 @default.
- W177621860 hasConceptScore W177621860C190062978 @default.
- W177621860 hasConceptScore W177621860C2779222958 @default.
- W177621860 hasConceptScore W177621860C55493867 @default.
- W177621860 hasConceptScore W177621860C86803240 @default.
- W177621860 hasConceptScore W177621860C95444343 @default.
- W177621860 hasIssue "10" @default.
- W177621860 hasLocation W1776218601 @default.
- W177621860 hasLocation W1776218602 @default.
- W177621860 hasLocation W1776218603 @default.
- W177621860 hasOpenAccess W177621860 @default.
- W177621860 hasPrimaryLocation W1776218601 @default.
- W177621860 hasRelatedWork W147767811 @default.
- W177621860 hasRelatedWork W1966922962 @default.
- W177621860 hasRelatedWork W2087642137 @default.
- W177621860 hasRelatedWork W2189095430 @default.
- W177621860 hasRelatedWork W2230950894 @default.
- W177621860 hasRelatedWork W2758791303 @default.
- W177621860 hasRelatedWork W2917539084 @default.
- W177621860 hasRelatedWork W3097867614 @default.
- W177621860 hasRelatedWork W884848843 @default.
- W177621860 hasRelatedWork W32854598 @default.
- W177621860 hasVolume "269" @default.
- W177621860 isParatext "false" @default.
- W177621860 isRetracted "false" @default.
- W177621860 magId "177621860" @default.
- W177621860 workType "article" @default.