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- W1776288360 abstract "ABSTRACT Experiments have been performed to help clarify the role of nonhomologies in phage λ recombination. Three-factor crosses were carried out, and the frequencies of single and double recombinants in the two adjoining intervals were compared when the central marker was either a double point mutation (v1v3) or deletion (rex-cI deletion) or nonhomologous substitution (imm434). In all cases the lefthand marker was a bio substitution (Fec- phenotype, which does not permit plating on recA -), and the righthand marker was an amber mutation in gene O. Experiments were performed in all four possible arrangements of the central and rightward markers, while selecting for the Fec+ phenotype on the recA - host. As anticipated, high negative interference (HNI) was observed with point mutations, but when the central marker was a substitution nonhomology, HNI was reduced about tenfold. Surprisingly, when the central marker was a simple deletion, a dramatic asymmetry in results was observed, with HNI being exhibited only when the central deletion marker was acquired by the double recombinant. These results indicate that under normal conditions (red +, gam +, rec +) and with noninhibited DNA replication, recombination in coliphage λ entails a highly asymmetric step that could be at the level of strand transfer or mismatch repair." @default.
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- W1776288360 date "1982-11-01" @default.
- W1776288360 modified "2023-09-27" @default.
- W1776288360 title "ASYMMETRIC EFFECTS OF DELETIONS AND SUBSTITUTIONS ON HIGH NEGATIVE INTERFERENCE IN COLIPHAGE LAMBDA" @default.
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- W1776288360 doi "https://doi.org/10.1093/genetics/102.3.299" @default.
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