FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1776354881> ?p ?o ?g. }

• W1776354881 endingPage "1654" @default.
• W1776354881 startingPage "1647" @default.
• W1776354881 abstract "Scavenger receptor (SR)-BI mediates the selective uptake of high density lipoprotein (HDL) cholesteryl esters and the efflux of free cholesterol. In Chinese hamster ovary (CHO) cells, SR-BI is predominantly associated with caveolae which we have recently demonstrated are the initial loci for membrane transfer of HDL cholesteryl esters. Because cholesterol accumulation in macrophages is a critical event in atherogenesis, we investigated the expression of SR-BI and caveolin-1 in several macrophage cell lines. Human THP-1 monocytes were examined before and after differentiation to macrophages by treatment with 200 nm phorbol ester for 72 h. Undifferentiated THP-1 cells expressed caveolin-1 weakly whereas differentiation up-regulated caveolin-1 expression greater than 50-fold. In contrast, both undifferentiated and differentiated THP-1 cells expressed similar levels of SR-BI. Differentiation of THP-1 cells increased the percent of membrane cholesterol associated with caveolae from 12% ± 1.9% to 38% ± 3.1%. The increase in caveolin-1 expression was associated with a 2- to 3-fold increase in selective cholesterol ether uptake from HDL. Two mouse macrophage cell lines, J774 and RAW, expressed levels of SR-BI similar to differentiated THP-1 cells but did not express detectable levels of caveolin-1. In comparison to differentiated THP-1 cells, RAW and J774 cells internalized 9- to 10-fold less cholesteryl ester.We conclude that differentiated THP-1 cells express both caveolin-1 and SR-BI and that their co-expression is associated with enhanced selective cholesteryl ester uptake.— Matveev, S., D. R. van der Westhuyzen, and E. J. Smart. Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages. J. Lipid Res. 1999. 40: 1647–1654." @default.
• W1776354881 created "2016-06-24" @default.
• W1776354881 creator A5044645853 @default.
• W1776354881 creator A5044742086 @default.
• W1776354881 creator A5058833764 @default.
• W1776354881 date "1999-09-01" @default.
• W1776354881 modified "2023-09-26" @default.
• W1776354881 title "Co-expression of scavenger receptor-BI and caveolin-1 is associated with enhanced selective cholesteryl ester uptake in THP-1 macrophages" @default.
• W1776354881 cites W1526016286 @default.
• W1776354881 cites W1574380753 @default.
• W1776354881 cites W1576930851 @default.
• W1776354881 cites W1631814726 @default.
• W1776354881 cites W1857052429 @default.
• W1776354881 cites W1947043095 @default.
• W1776354881 cites W1971700135 @default.
• W1776354881 cites W1985170971 @default.
• W1776354881 cites W1996156489 @default.
• W1776354881 cites W1997678048 @default.
• W1776354881 cites W1999743098 @default.
• W1776354881 cites W2005175065 @default.
• W1776354881 cites W2007512974 @default.
• W1776354881 cites W2021133118 @default.
• W1776354881 cites W2022561687 @default.
• W1776354881 cites W2022690810 @default.
• W1776354881 cites W2032190558 @default.
• W1776354881 cites W2032731208 @default.
• W1776354881 cites W2040945595 @default.
• W1776354881 cites W2047543639 @default.
• W1776354881 cites W2048978769 @default.
• W1776354881 cites W2053204073 @default.
• W1776354881 cites W2059895279 @default.
• W1776354881 cites W2062030534 @default.
• W1776354881 cites W2063358283 @default.
• W1776354881 cites W2066812102 @default.
• W1776354881 cites W2069444054 @default.
• W1776354881 cites W2076490603 @default.
• W1776354881 cites W2082964386 @default.
• W1776354881 cites W2083446323 @default.
• W1776354881 cites W2088432812 @default.
• W1776354881 cites W2091015159 @default.
• W1776354881 cites W2094162221 @default.
• W1776354881 cites W2107461689 @default.
• W1776354881 cites W2112465136 @default.
• W1776354881 cites W2128963767 @default.
• W1776354881 cites W2133388060 @default.
• W1776354881 cites W2144760773 @default.
• W1776354881 cites W2151426663 @default.
• W1776354881 cites W2153689647 @default.
• W1776354881 cites W2156590312 @default.
• W1776354881 cites W2187911644 @default.
• W1776354881 cites W2224266189 @default.
• W1776354881 cites W4300662030 @default.
• W1776354881 doi "https://doi.org/10.1016/s0022-2275(20)33410-6" @default.
• W1776354881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10484611" @default.
• W1776354881 hasPublicationYear "1999" @default.
• W1776354881 type Work @default.
• W1776354881 sameAs 1776354881 @default.
• W1776354881 citedByCount "124" @default.
• W1776354881 countsByYear W17763548812012 @default.
• W1776354881 countsByYear W17763548812013 @default.
• W1776354881 countsByYear W17763548812014 @default.
• W1776354881 countsByYear W17763548812015 @default.
• W1776354881 countsByYear W17763548812016 @default.
• W1776354881 countsByYear W17763548812017 @default.
• W1776354881 countsByYear W17763548812018 @default.
• W1776354881 countsByYear W17763548812019 @default.
• W1776354881 countsByYear W17763548812020 @default.
• W1776354881 countsByYear W17763548812021 @default.
• W1776354881 countsByYear W17763548812022 @default.
• W1776354881 countsByYear W17763548812023 @default.
• W1776354881 crossrefType "journal-article" @default.
• W1776354881 hasAuthorship W1776354881A5044645853 @default.
• W1776354881 hasAuthorship W1776354881A5044742086 @default.
• W1776354881 hasAuthorship W1776354881A5058833764 @default.
• W1776354881 hasBestOaLocation W17763548811 @default.
• W1776354881 hasConcept C1491633281 @default.
• W1776354881 hasConcept C153911025 @default.
• W1776354881 hasConcept C170493617 @default.
• W1776354881 hasConcept C175656101 @default.
• W1776354881 hasConcept C185592680 @default.
• W1776354881 hasConcept C204258353 @default.
• W1776354881 hasConcept C2776448209 @default.
• W1776354881 hasConcept C2777895019 @default.
• W1776354881 hasConcept C2778163477 @default.
• W1776354881 hasConcept C2780072125 @default.
• W1776354881 hasConcept C41443022 @default.
• W1776354881 hasConcept C49866891 @default.
• W1776354881 hasConcept C54355233 @default.
• W1776354881 hasConcept C55493867 @default.
• W1776354881 hasConcept C81885089 @default.
• W1776354881 hasConcept C86803240 @default.
• W1776354881 hasConcept C95444343 @default.
• W1776354881 hasConceptScore W1776354881C1491633281 @default.
• W1776354881 hasConceptScore W1776354881C153911025 @default.
• W1776354881 hasConceptScore W1776354881C170493617 @default.
• W1776354881 hasConceptScore W1776354881C175656101 @default.
• W1776354881 hasConceptScore W1776354881C185592680 @default.
• W1776354881 hasConceptScore W1776354881C204258353 @default.

• next