FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W17763602> ?p ?o ?g. }

• W17763602 endingPage "20" @default.
• W17763602 startingPage "11" @default.
• W17763602 abstract "Rationale. The cannabinoid system consists of a complex array of receptors, substances with agonist/antagonist properties for those receptors, biosynthetic machineries and mechanisms for cellular uptake and degradation for endocannabinoids. This system is in interrelation with other systems that comprise lipid mediators like prostaglandins/leukotrienes systems. A clear antagonist, additive or synergic effect of nonsteroidal anti–inflammatory drugs (NSAIDs)–cannabinoid associations was not yet demonstrated. Aim. The present study tried to summarize the existent data on NSAIDS-cannabinoid system interactions. Methods and results A bibliographic research in Medline, Scirus, Embase was made using as keywords cannabinoid, nonsteroidal anti–inflammatory drugs, aspirin, ibuprofen, flurbiprofen, diclofenac, indomethacin, acetaminophen, coxibs, antinociceptive, antinociception, analgesia DiscussionsA systematization of the results focusing on the NSAIDs drugs interaction with the cannabinoid system was presented. Out of all the substances analyzed in the present review, acetaminophen was studied the most regarding its interferences with the cannabinoid system, mainly due to contradictory results. Conclusions Some NSAIDs have additional influences on the cannabinoid system either by inhibiting fatty acid amide hydrolase (FAAH) or by inhibiting a possible intracellular transporter of endocannabinoids. All the NSAIDs that inhibit COX2 can influence the cannabinoid system because a possible important degradative pathway for anandamide and 2–arachidonoyl glycerol might involve COX 2. One of the causes for the variety of experimental results presented might be due to pharmacokinetic mechanisms, depending on the route of administration and the doseAbbreviationsdelta9 THC, (–)–(6aR,10aR)–6,6,9–trimethyl–3–pentyl–6a,7,8,10a–tetrahydro–6H–benzo[c]chromen–1–ol; delta9–THC–11–oic acid, 1–hydroxy–6,6–dimethyl–3–pentyl–6a,7,8,10a–tetrahydrobenzo[c] chromene–9–carboxylic acid; Anandamide, (5Z,8Z,11Z,14Z)–N–(2–hydroxyethyl)icosa–5,8,11,14–tetraenamide; Methanandamide, (5Z,8Z,11Z,14Z)–N–[(2R)–1–hydroxypropan–2–yl]–icosa–5,8,11,14–tetraenamide; 2–AG, 1,3–Dihydroxy–2–propanyl (5Z,8Z,11Z,14Z)–5,8,11,14–eicosatetraenoate; HU 210, (6aR,10aR)– 9–(Hydroxymethyl)–6,6–dimethyl–3–(2–methyloctan–2–yl)–6a,7,10,10a–tetrahydrobenzo [c]chromen–1–ol; SR141716A, 5–(4–Chlorophenyl)–1–(2,4–dichloro–phenyl)–4–methyl–N–(piperidin–1–yl)–1H–pyrazole–3–carboxamide; SR144528, N–[(1S)–endo–1,3,3–trimethyl bicyclo [2.2.1] heptan–2–yl]–5–(4–chloro–3–methylphenyl)–1–(4–methylbenzyl)–pyrazole–3–carboxamide; AM251, 1–(2,4–dichlorophenyl)–5–(4–iodophenyl)–4–methyl–N–(1–piperidyl)pyrazole–3–carboxamide; AM 404, (5Z,8Z,11Z,14Z)–N–(4–hydroxyphenyl)icosa–5,8,11,14–tetraenamide; WIN 55,212–2, (R)–(+)–[2,3–Dihydro–5–methyl– 3–(4–morpholinylmethyl)pyrrolo [1,2,3–de]–1,4–benzoxazin–6–yl]–1–napthalenylmethanone; AM 281, N–(morpholin–4–yl)–5–(4–iodophenyl)–1–(2,4–dichlorphenyl)–4–methyl–1H–pyrazole–3–carboxamide; AM 630, [6–Iodo–2–methyl–1–[2–(4–morpholinyl)ethyl]–1H–indol–3–yl](4–methoxyphenyl)methanone; Ibu Am–5, N–(3–methylpyridin–2–yl)–2–(4'–isobutylphenyl)propionamide; CP 55, 940, 2–[(1R,2R,5R)–5–hydroxy–2–(3–hydroxypropyl) cyclohexyl]–5–(2–methyloctan–2–yl)phenol; NS–398, N–[2–(Cyclohexyloxy)–4–nitrophenyl]methanesulfonamide; SC–560, 5–(4–chlorophenyl)–1–(4–methoxyphenyl)–3–trifluoromethylpyrazole; AM 1241, (3–iodo–5–nitrophenyl)–[1–[(1–methylpiperidin–2–yl)methyl]indol–3–yl]methanone; Met F AEA, 2–methyl–arachidonyl–2'–fluoro–ethylamide; PMSF, Phenylmethylsulfonyl fluoride; URB 597, [3–(3–carbamoylphenyl)phenyl] N–cyclohexylcarbamate; TRPV1, Transient receptor potential vanilloid type 1; CGRP, Calcitonin gene related peptide; COX1, cyclooxygenase type 1; COX2, cyclooxygenase type 2; CB1R, cannabinoid receptor type 1; CB2R, cannabinoid receptor type 2; FAAH, fatty acid amide hydrolase; NSAIDs, nonsteroidal anti–inflammatory drugs; p.o., per os; i.p., intraperitoneally; i.th., intrathecally; s.c. subcutaneously; i.pl., intraplantar; i.v., intravenously; CB cannabinoid." @default.
• W17763602 created "2016-06-24" @default.
• W17763602 creator A5010465524 @default.
• W17763602 creator A5015391998 @default.
• W17763602 creator A5015764514 @default.
• W17763602 creator A5035636294 @default.
• W17763602 creator A5037167638 @default.
• W17763602 creator A5068937816 @default.
• W17763602 creator A5076931375 @default.
• W17763602 date "2011-02-15" @default.
• W17763602 modified "2023-10-18" @default.
• W17763602 title "Cannabinoid system and cyclooxygenases inhibitors." @default.
• W17763602 cites W1482895394 @default.
• W17763602 cites W1570021829 @default.
• W17763602 cites W169168310 @default.
• W17763602 cites W1928528795 @default.
• W17763602 cites W1964840757 @default.
• W17763602 cites W1966648294 @default.
• W17763602 cites W1977748966 @default.
• W17763602 cites W1987354140 @default.
• W17763602 cites W1987775880 @default.
• W17763602 cites W1994410805 @default.
• W17763602 cites W1996263740 @default.
• W17763602 cites W2001498827 @default.
• W17763602 cites W2014186264 @default.
• W17763602 cites W2024800451 @default.
• W17763602 cites W2026146917 @default.
• W17763602 cites W2028025615 @default.
• W17763602 cites W2029735397 @default.
• W17763602 cites W2033278366 @default.
• W17763602 cites W2036864402 @default.
• W17763602 cites W2037382867 @default.
• W17763602 cites W2044528871 @default.
• W17763602 cites W2053304919 @default.
• W17763602 cites W2057217973 @default.
• W17763602 cites W2074776864 @default.
• W17763602 cites W2080429677 @default.
• W17763602 cites W2083970703 @default.
• W17763602 cites W2090462084 @default.
• W17763602 cites W2119551996 @default.
• W17763602 cites W2130587723 @default.
• W17763602 cites W2132903646 @default.
• W17763602 cites W2143807655 @default.
• W17763602 cites W2160265565 @default.
• W17763602 cites W2168128112 @default.
• W17763602 cites W2171125004 @default.
• W17763602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3056416" @default.
• W17763602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21505570" @default.
• W17763602 hasPublicationYear "2011" @default.
• W17763602 type Work @default.
• W17763602 sameAs 17763602 @default.
• W17763602 citedByCount "17" @default.
• W17763602 countsByYear W177636022012 @default.
• W17763602 countsByYear W177636022013 @default.
• W17763602 countsByYear W177636022014 @default.
• W17763602 countsByYear W177636022015 @default.
• W17763602 countsByYear W177636022017 @default.
• W17763602 countsByYear W177636022018 @default.
• W17763602 countsByYear W177636022019 @default.
• W17763602 countsByYear W177636022020 @default.
• W17763602 countsByYear W177636022021 @default.
• W17763602 countsByYear W177636022022 @default.
• W17763602 countsByYear W177636022023 @default.
• W17763602 crossrefType "journal-article" @default.
• W17763602 hasAuthorship W17763602A5010465524 @default.
• W17763602 hasAuthorship W17763602A5015391998 @default.
• W17763602 hasAuthorship W17763602A5015764514 @default.
• W17763602 hasAuthorship W17763602A5035636294 @default.
• W17763602 hasAuthorship W17763602A5037167638 @default.
• W17763602 hasAuthorship W17763602A5068937816 @default.
• W17763602 hasAuthorship W17763602A5076931375 @default.
• W17763602 hasConcept C148001335 @default.
• W17763602 hasConcept C170493617 @default.
• W17763602 hasConcept C185592680 @default.
• W17763602 hasConcept C2776158853 @default.
• W17763602 hasConcept C2778938600 @default.
• W17763602 hasConcept C2779783865 @default.
• W17763602 hasConcept C2780871563 @default.
• W17763602 hasConcept C2781000538 @default.
• W17763602 hasConcept C2781144285 @default.
• W17763602 hasConcept C2910065304 @default.
• W17763602 hasConcept C46721173 @default.
• W17763602 hasConcept C55493867 @default.
• W17763602 hasConcept C71924100 @default.
• W17763602 hasConcept C98274493 @default.
• W17763602 hasConceptScore W17763602C148001335 @default.
• W17763602 hasConceptScore W17763602C170493617 @default.
• W17763602 hasConceptScore W17763602C185592680 @default.
• W17763602 hasConceptScore W17763602C2776158853 @default.
• W17763602 hasConceptScore W17763602C2778938600 @default.
• W17763602 hasConceptScore W17763602C2779783865 @default.
• W17763602 hasConceptScore W17763602C2780871563 @default.
• W17763602 hasConceptScore W17763602C2781000538 @default.
• W17763602 hasConceptScore W17763602C2781144285 @default.
• W17763602 hasConceptScore W17763602C2910065304 @default.
• W17763602 hasConceptScore W17763602C46721173 @default.
• W17763602 hasConceptScore W17763602C55493867 @default.
• W17763602 hasConceptScore W17763602C71924100 @default.

• next