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• W1776383313 startingPage "1724" @default.
• W1776383313 abstract "Timing of embryonic development is precisely controlled, but the mechanisms underlying biological timers are still unclear. Here, a validated model for timing under control of Sonic Hedgehog is revisited and generalized to an arbitrary number of genes. The developmental dynamics where a temporal sequence of gene expression recapitulates a steady-state spatial pattern can be realized through a simple network close to criticality, controlled by the duration of exposure to a morphogen. Criticality simultaneously accounts for many observed biological properties, such as timing, multistability, and canalization of genetic expression. This process can be parsimoniously generalized in many dimensions with a minimum number of genes, all repressing each other with asymmetrical strengths, which also explains sequential activation of different fates. Separation of timescales allows for a simple analytical interpretation. Finally, it is shown that even in the presence of noise, coupling between cells preserves criticality and robust patterning. The model offers a simple theoretical framework for the study of emergent developmental timers." @default.
• W1776383313 created "2016-06-24" @default.
• W1776383313 creator A5056287697 @default.
• W1776383313 creator A5077758535 @default.
• W1776383313 date "2015-10-01" @default.
• W1776383313 modified "2023-09-26" @default.
• W1776383313 title "Critical Timing without a Timer for Embryonic Development" @default.
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• W1776383313 doi "https://doi.org/10.1016/j.bpj.2015.08.024" @default.
• W1776383313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4624113" @default.
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