Matches in SemOpenAlex for { <https://semopenalex.org/work/W1776706358> ?p ?o ?g. }
- W1776706358 endingPage "1388" @default.
- W1776706358 startingPage "1381" @default.
- W1776706358 abstract "The flavonoid quercetin and its derivative rutin were investigated for genotoxicity/antigenotoxicity activity in human hepatoma HepG2 cells using the comet assay. The extract cytotoxicity was evaluated using the trypan blue exclusion dye method with quercetin and rutin concentrations ranging from 0.1 to 200.0 μg/mL of culture medium. Three minor non-cytotoxic concentrations were chosen to evaluate the genotoxicity and antigenotoxicity of the flavonoids (0.1, 1.0 and 5.0 μg/mL) through comet assay. The cultures were treated with three different concentrations of rutin or quercetin (genotoxicity) or their association with Aflatoxin B1 (AFB1), methyl methanesulfonate (MMS) or doxorubicin (DXR) (antigenotoxicity test) in three protocols: pre-treatment, simultaneous treatment and post-treatment. The cell cultures were also treated with 1% DMSO (control group), AFB1, MMS and DXR (positive-control). Statistical analyses were performed using ANOVA and Dunnett's test (p ≤ 0.05). Quercetin at concentrations higher than 10.0 μg/mL or rutin higher than 50.0 μg/mL exhibited a cytotoxic effect on the cells, showing that quercetin is more cytotoxic than rutin. Furthermore, neither compound was able to induce genotoxicity in the concentrations evaluated. On the other hand, both flavonoids reduced DNA damage induced by AFB1, MMS and DXR in all treatment protocols. Copyright © 2011 John Wiley & Sons, Ltd." @default.
- W1776706358 created "2016-06-24" @default.
- W1776706358 creator A5001273219 @default.
- W1776706358 creator A5006743509 @default.
- W1776706358 creator A5009006232 @default.
- W1776706358 creator A5013079928 @default.
- W1776706358 creator A5075123727 @default.
- W1776706358 creator A5082107048 @default.
- W1776706358 creator A5086937956 @default.
- W1776706358 date "2011-02-24" @default.
- W1776706358 modified "2023-10-18" @default.
- W1776706358 title "Evaluation of Antigenotoxic Effects of Plant Flavonoids Quercetin and Rutin on HepG2 Cells" @default.
- W1776706358 cites W1497621324 @default.
- W1776706358 cites W1541649582 @default.
- W1776706358 cites W1606710785 @default.
- W1776706358 cites W1923068753 @default.
- W1776706358 cites W1963656017 @default.
- W1776706358 cites W1966700699 @default.
- W1776706358 cites W1970162702 @default.
- W1776706358 cites W1970299053 @default.
- W1776706358 cites W1972165860 @default.
- W1776706358 cites W1977672230 @default.
- W1776706358 cites W1978840408 @default.
- W1776706358 cites W1979189704 @default.
- W1776706358 cites W1987021965 @default.
- W1776706358 cites W1991808160 @default.
- W1776706358 cites W1995286122 @default.
- W1776706358 cites W1998008670 @default.
- W1776706358 cites W1998917614 @default.
- W1776706358 cites W2004594798 @default.
- W1776706358 cites W2010807769 @default.
- W1776706358 cites W2014978180 @default.
- W1776706358 cites W2016000854 @default.
- W1776706358 cites W2028377177 @default.
- W1776706358 cites W2028426479 @default.
- W1776706358 cites W2033624890 @default.
- W1776706358 cites W2046263460 @default.
- W1776706358 cites W2056842005 @default.
- W1776706358 cites W2058354970 @default.
- W1776706358 cites W2061142443 @default.
- W1776706358 cites W2073878689 @default.
- W1776706358 cites W2074672869 @default.
- W1776706358 cites W2079432627 @default.
- W1776706358 cites W2081889520 @default.
- W1776706358 cites W2085786747 @default.
- W1776706358 cites W2087921012 @default.
- W1776706358 cites W2095526611 @default.
- W1776706358 cites W2102752109 @default.
- W1776706358 cites W2104478003 @default.
- W1776706358 cites W2105209500 @default.
- W1776706358 cites W2121868928 @default.
- W1776706358 cites W2122627366 @default.
- W1776706358 cites W2126902508 @default.
- W1776706358 cites W2127642751 @default.
- W1776706358 cites W2127741212 @default.
- W1776706358 cites W2139014218 @default.
- W1776706358 cites W2144312770 @default.
- W1776706358 cites W2153473625 @default.
- W1776706358 cites W2157002083 @default.
- W1776706358 cites W2164755041 @default.
- W1776706358 cites W2171992272 @default.
- W1776706358 cites W2172298586 @default.
- W1776706358 cites W9294019 @default.
- W1776706358 doi "https://doi.org/10.1002/ptr.3436" @default.
- W1776706358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25363758" @default.
- W1776706358 hasPublicationYear "2011" @default.
- W1776706358 type Work @default.
- W1776706358 sameAs 1776706358 @default.
- W1776706358 citedByCount "38" @default.
- W1776706358 countsByYear W17767063582012 @default.
- W1776706358 countsByYear W17767063582013 @default.
- W1776706358 countsByYear W17767063582014 @default.
- W1776706358 countsByYear W17767063582015 @default.
- W1776706358 countsByYear W17767063582016 @default.
- W1776706358 countsByYear W17767063582017 @default.
- W1776706358 countsByYear W17767063582018 @default.
- W1776706358 countsByYear W17767063582019 @default.
- W1776706358 countsByYear W17767063582020 @default.
- W1776706358 countsByYear W17767063582021 @default.
- W1776706358 countsByYear W17767063582022 @default.
- W1776706358 countsByYear W17767063582023 @default.
- W1776706358 crossrefType "journal-article" @default.
- W1776706358 hasAuthorship W1776706358A5001273219 @default.
- W1776706358 hasAuthorship W1776706358A5006743509 @default.
- W1776706358 hasAuthorship W1776706358A5009006232 @default.
- W1776706358 hasAuthorship W1776706358A5013079928 @default.
- W1776706358 hasAuthorship W1776706358A5075123727 @default.
- W1776706358 hasAuthorship W1776706358A5082107048 @default.
- W1776706358 hasAuthorship W1776706358A5086937956 @default.
- W1776706358 hasConcept C109316439 @default.
- W1776706358 hasConcept C143425029 @default.
- W1776706358 hasConcept C178790620 @default.
- W1776706358 hasConcept C185592680 @default.
- W1776706358 hasConcept C202751555 @default.
- W1776706358 hasConcept C2775963812 @default.
- W1776706358 hasConcept C2778004101 @default.
- W1776706358 hasConcept C2778959862 @default.
- W1776706358 hasConcept C2779054382 @default.