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- W177695731 abstract "Male Sprague-Dawley rats, deficient in thiamine, were given 7.5% w/v ethanol (EtOH) as the sole fluid for 24 hours in association with i.p. injection of 267 μg/kg thiamine; rats were again rendered deficient and were recovered 2 more times in association with EtOH. Intake averaged about 12 g/kg/day on the 3 recovery days. A home cage fluid choice when no longer deficient followed the third recovery. EtOH intake averaged greater than 13 g/kg/day in initial days of the choice situation; mean intake remained above 8 g/kg/day for the first 10 choice days. Blood alcohol levels under self-selection in similar studies verified that patterns of intake were pharmacologically effective. Learned preferences, due to their trans-situational nature, appear to be a promising approach to long-term modification of volitional alcohol consumption by laboratory animals." @default.
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- W177695731 date "1977-01-01" @default.
- W177695731 modified "2023-09-27" @default.
- W177695731 title "LEARNED PREFERENCES AS AN APPROACH TO THE DEVELOPMENT OF AN ANIMAL MODEL OF ALCOHOLISM" @default.
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- W177695731 doi "https://doi.org/10.1016/b978-0-12-691403-0.50068-9" @default.
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