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- W1777007622 abstract "INTRODUCTION: In the beginning of year 2000 Mundy et al. showed that simvastatin, a drug administered for high cholesterol levels, had a profound stimulatory effect on osteoblasts [1]. Since then other studies have confirmed that locally applied simvastatin enhances bone formation [2]; however, the lack of a local delivery system have restricted its clinical use. We have used a premixed acidic calcium phosphate cement as a local delivery system. The release kinetics of simvastatin from this cement was measured. Moreover the effect of the released simvastatin was assessed by mineralization and viability assay with human osteoblast-like cells." @default.
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- W1777007622 date "2012-01-01" @default.
- W1777007622 modified "2023-09-30" @default.
- W1777007622 title "Premixed acidic calcium phosphate cement: delivery system for simvastatin" @default.
- W1777007622 hasPublicationYear "2012" @default.
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