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- W177718421 abstract "Medullary thyroid carcinoma (MTC) is a neoplasm derived from the calcitonin producing or C cells of the thyroid gland. The C cell is a neuroendocrine cell that is distributed throughout the thyroid gland in mammalian species with the greatest concentration of cells located centrally at the junction of the upper one-third and lower two-thirds of each lobe. In birds and bony fish the C cells are located in a single discrete gland called the ultimobranchial body. These cells migrate during embryologic life from the neural crest (1,2). The recent discovery of a molecular basis for approximately one-half of all medullary thyroid carcinomas has not only provided insight into the process of transformation, but has also elucidated a potential mechanism for directing migration of neural crest cells to several different anatomic locations." @default.
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- W177718421 date "1998-01-01" @default.
- W177718421 modified "2023-09-25" @default.
- W177718421 title "Pathogenesis of Medullary Thyroid Carcinoma" @default.
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- W177718421 doi "https://doi.org/10.1007/978-1-4615-4945-1_4" @default.
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