Matches in SemOpenAlex for { <https://semopenalex.org/work/W177730594> ?p ?o ?g. }
- W177730594 endingPage "7" @default.
- W177730594 startingPage "633" @default.
- W177730594 abstract "We investigated the cellular requirement for primary in vitro generation of cytotoxic T-lymphocytes (CTL) in BALB/c spleen cells against Ld-binding self-peptide p2Ca. Depletion of CD4+ T-cells in vitro by pretreatment with anti-CD4 monoclonal antibody (mAb) and complement or in vivo by administration of anti-CD4 mAb abrogated generation of CTL. Depletion of adherent cells by passing spleen cells through a nylon wool (NW) column also abrogated generation of CTL. Addition of peritoneal exudate cells (PEC) to spleen cells passed through the NW column restored CTL generation. These findings indicate that both CD4+ T-cells and antigen-presenting cells (APC) were necessary for CTL generation. Treatment of PEC with paraformaldehyde (PFA), but not mitomycin-C (MMC) abrogated their ability to restore CTL generation when mixed with spleen cells from the NW column, suggesting that an endocytic pathway could be involved in presentation of p2Ca on APC." @default.
- W177730594 created "2016-06-24" @default.
- W177730594 creator A5010226955 @default.
- W177730594 creator A5024225553 @default.
- W177730594 creator A5037320870 @default.
- W177730594 creator A5060857583 @default.
- W177730594 creator A5079949895 @default.
- W177730594 date "1995-04-01" @default.
- W177730594 modified "2023-10-18" @default.
- W177730594 title "Requirement of CD4+ T cells and antigen-presenting cells for primary in vitro generation of CD8+ cytotoxic T cells against Ld-binding self-peptide p2Ca." @default.
- W177730594 cites W1486736995 @default.
- W177730594 cites W1497278722 @default.
- W177730594 cites W1559147122 @default.
- W177730594 cites W1562306078 @default.
- W177730594 cites W1600662889 @default.
- W177730594 cites W1980897291 @default.
- W177730594 cites W1981366552 @default.
- W177730594 cites W1990806106 @default.
- W177730594 cites W1995129175 @default.
- W177730594 cites W2008564146 @default.
- W177730594 cites W2009870709 @default.
- W177730594 cites W2020599427 @default.
- W177730594 cites W2021102872 @default.
- W177730594 cites W2022297663 @default.
- W177730594 cites W2046760991 @default.
- W177730594 cites W2048310562 @default.
- W177730594 cites W2052357793 @default.
- W177730594 cites W2052383501 @default.
- W177730594 cites W2056822624 @default.
- W177730594 cites W2060912331 @default.
- W177730594 cites W2078905610 @default.
- W177730594 cites W2087286958 @default.
- W177730594 cites W2090295166 @default.
- W177730594 cites W2092675894 @default.
- W177730594 cites W2106628245 @default.
- W177730594 cites W2117582013 @default.
- W177730594 cites W2118887037 @default.
- W177730594 cites W2140985128 @default.
- W177730594 cites W2142747913 @default.
- W177730594 cites W2172009488 @default.
- W177730594 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1415149" @default.
- W177730594 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7790038" @default.
- W177730594 hasPublicationYear "1995" @default.
- W177730594 type Work @default.
- W177730594 sameAs 177730594 @default.
- W177730594 citedByCount "2" @default.
- W177730594 crossrefType "journal-article" @default.
- W177730594 hasAuthorship W177730594A5010226955 @default.
- W177730594 hasAuthorship W177730594A5024225553 @default.
- W177730594 hasAuthorship W177730594A5037320870 @default.
- W177730594 hasAuthorship W177730594A5060857583 @default.
- W177730594 hasAuthorship W177730594A5079949895 @default.
- W177730594 hasConcept C129374314 @default.
- W177730594 hasConcept C147483822 @default.
- W177730594 hasConcept C147969180 @default.
- W177730594 hasConcept C153911025 @default.
- W177730594 hasConcept C154317977 @default.
- W177730594 hasConcept C167672396 @default.
- W177730594 hasConcept C185592680 @default.
- W177730594 hasConcept C202751555 @default.
- W177730594 hasConcept C203014093 @default.
- W177730594 hasConcept C2780931953 @default.
- W177730594 hasConcept C55493867 @default.
- W177730594 hasConcept C67662055 @default.
- W177730594 hasConcept C83464605 @default.
- W177730594 hasConcept C86803240 @default.
- W177730594 hasConcept C95444343 @default.
- W177730594 hasConceptScore W177730594C129374314 @default.
- W177730594 hasConceptScore W177730594C147483822 @default.
- W177730594 hasConceptScore W177730594C147969180 @default.
- W177730594 hasConceptScore W177730594C153911025 @default.
- W177730594 hasConceptScore W177730594C154317977 @default.
- W177730594 hasConceptScore W177730594C167672396 @default.
- W177730594 hasConceptScore W177730594C185592680 @default.
- W177730594 hasConceptScore W177730594C202751555 @default.
- W177730594 hasConceptScore W177730594C203014093 @default.
- W177730594 hasConceptScore W177730594C2780931953 @default.
- W177730594 hasConceptScore W177730594C55493867 @default.
- W177730594 hasConceptScore W177730594C67662055 @default.
- W177730594 hasConceptScore W177730594C83464605 @default.
- W177730594 hasConceptScore W177730594C86803240 @default.
- W177730594 hasConceptScore W177730594C95444343 @default.
- W177730594 hasIssue "4" @default.
- W177730594 hasLocation W1777305941 @default.
- W177730594 hasOpenAccess W177730594 @default.
- W177730594 hasPrimaryLocation W1777305941 @default.
- W177730594 hasRelatedWork W1545991286 @default.
- W177730594 hasRelatedWork W1560891208 @default.
- W177730594 hasRelatedWork W1593392947 @default.
- W177730594 hasRelatedWork W1935404225 @default.
- W177730594 hasRelatedWork W1967412705 @default.
- W177730594 hasRelatedWork W1967600221 @default.
- W177730594 hasRelatedWork W1998498677 @default.
- W177730594 hasRelatedWork W2014778085 @default.
- W177730594 hasRelatedWork W2104138107 @default.
- W177730594 hasRelatedWork W4246661564 @default.
- W177730594 hasVolume "84" @default.
- W177730594 isParatext "false" @default.