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• W1777403683 abstract "Using evidence from short-term randomized controlled trials, decision-analytic models project costs, risks and benefits of disease-modifying therapies (DMTs) for multiple sclerosis (MS). Such trial-informed models lack the breadth needed to generalize to clinical practice or policy due to limitations: lack of DMT switching/discontinuation, limited head-to-head DMT comparisons and efficacy, not effectiveness, designs. We present an illustrative example that incorporates treatment switching and discontinuation by estimating the cost-effectiveness (value) of first-line natalizumab versus second-line natalizumab treatment for relapsing-remitting MS patients negative for anti-JC virus antibodies. Treating JC virus-negative relapsing-remitting MS patients with natalizumab as first-line provided better value compared with second-line. Decision-makers should consider this evidence for treatment step-edit policies through modeling scenarios closer to clinical practice." @default.
• W1777403683 created "2016-06-24" @default.
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• W1777403683 date "2015-08-20" @default.
• W1777403683 modified "2023-09-27" @default.
• W1777403683 title "Incorporating real-world clinical practice in multiple sclerosis economic evaluations" @default.
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• W1777403683 doi "https://doi.org/10.1586/14737167.2015.1081060" @default.
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