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- W1777451708 abstract "The application of the concepts of physical organic chemistry to the understanding of mechanisms of enzyme action constitutes one of the major triumphs of our science. Many important discoveries in two diverse fields laid the foundation for the understanding of the mechanisms of enzyme action. The application of reaction kinetics, of the spectroscopic identification of intermediates; the trapping of intermediates; the understanding of acid and base catalysis, of metal–ion catalysis; the use of isotopes as tracers; and for the determination of kinetic isotope effects, and much more, provided the intellectual armament needed to solve problems in enzymology. The chapter explores that mechanistic enzymology has developed at a rapid pace since 1963 and the artificial catalysts in 1902 appear within the realm of possibility. Enzymologists have reasonable notions of mechanism and of the factors needed to achieve rapid rates and specificity. The chapter also reviews that the foundations for mechanism and to some extent for an understanding of the factors relevant to enzymology were laid down in the years 1947–1963. By the end of that time, enzymology had become incorporated into physical organic chemistry." @default.
- W1777451708 created "2016-06-24" @default.
- W1777451708 creator A5000358488 @default.
- W1777451708 date "1985-01-01" @default.
- W1777451708 modified "2023-09-26" @default.
- W1777451708 title "The Discovery of the Mechanisms of Enzyme Action, 1947–1963" @default.
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