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- W177755544 abstract "Periodical changes in resting membrane potential occur during pregnancy in rat myometrium. This chapter discusses a study to examine 4-aminopyridine (4-AP) and outward membrane currents in rat uterine smooth muscle at various stages of pregnancy. The measurements of intracellular ionic concentrations indicated that the ionic content of smooth muscle cells remained constant suggesting that the resting membrane displacement was caused by a change in membrane conductance, especially the potassium conductance. 4-AP, a potent inhibitor of the potassium channels in many excitable tissues, was used in the present study to clarify the evolution of the potassium outward current during different stages of gestation. Small strips from the longitudinal smooth muscle layer of the pregnant rat myometrium were used. These muscular strips were current and voltage-clamped by means of a double sucrose gap apparatus. The results suggest that during the gestation, the potassium conductance of the uterine membrane is governed by two sets of channels: (1) a first set of fast potassium channels is available from −80 mV and very sensitive to 4-AP and (2) a second set of potassium channels is insensitive to 4-AP and could be activated by the internal calcium concentration." @default.
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- W177755544 date "1982-01-01" @default.
- W177755544 modified "2023-09-24" @default.
- W177755544 title "4-Aminopyridine and Outward Membrane Currents in Rat Uterine Smooth Muscle at Various Stages of Pregnancy" @default.
- W177755544 doi "https://doi.org/10.1016/b978-0-08-028000-4.50059-2" @default.
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