FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1777564233> ?p ?o ?g. }

• W1777564233 endingPage "91" @default.
• W1777564233 startingPage "6583" @default.
• W1777564233 abstract "It is well established that ErbB1 and ErbB2 can cooperate in mammary epithelial cell transformation. Therefore, to understand how ErbB1/ErbB2 signaling contributes to this process, we used the ErbB kinase inhibitor AG1478in ErbB2-dependent BT-474 and SKBR-3 human breast cancer cells. These cells overexpress ErbB2 and also display moderate levels of ErbB1. Treatment with AG1478 resulted in rapid ErbB2 dephosphorylation, reversible G(1) arrest, and interruption of constitutive mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling. Consequently, both MAPK-dependent transcription of cyclin D1 and phosphorylation of the cyclin-dependent kinase (Cdk) inhibitor p27 were inhibited. The inhibition of PI3K/Akt resulted in increased activity of glycogen synthase kinase-3beta, which phosphorylated cyclin D1, potentially reducing its steady-state levels. The loss of cyclin D1 reduced the amount of cyclin D1/Cdk4 complexes that can sequester p27 in the cytosol. This plus the reduced phosphorylation of p27 by MAPK enhanced the stability of p27 that associated with nuclear Cdk2 at high stoichiometry and inhibited its kinase activity. Antisense p27 oligonucleotides decreased p27 levels and abrogated the G(1) arrest induced by AG1478. Similarly, infection with an adenovirus encoding inducible cyclin D1 also counteracted the antiproliferative effect of AG1478. These data imply that: (a) modulation of both p27 and cyclin D1 are required for the growth arrest that results from blockade of the ErbB2 kinase; and (b) ErbB2 overexpressing cells use both MAPK and PI3K/Akt to modulate p27 and cyclin D1 and, hence, subvert the G(1)-to-S transition." @default.
• W1777564233 created "2016-06-24" @default.
• W1777564233 creator A5020912420 @default.
• W1777564233 creator A5027476065 @default.
• W1777564233 creator A5035312473 @default.
• W1777564233 creator A5043946489 @default.
• W1777564233 creator A5080654301 @default.
• W1777564233 date "2001-09-01" @default.
• W1777564233 modified "2023-09-23" @default.
• W1777564233 title "ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways." @default.
• W1777564233 cites W103445271 @default.
• W1777564233 cites W1529396499 @default.
• W1777564233 cites W1582187753 @default.
• W1777564233 cites W1590978853 @default.
• W1777564233 cites W1601571585 @default.
• W1777564233 cites W1889928106 @default.
• W1777564233 cites W1893360284 @default.
• W1777564233 cites W1933350662 @default.
• W1777564233 cites W1964321121 @default.
• W1777564233 cites W1971981377 @default.
• W1777564233 cites W1990109052 @default.
• W1777564233 cites W1995993550 @default.
• W1777564233 cites W1996413533 @default.
• W1777564233 cites W2005075550 @default.
• W1777564233 cites W2014053430 @default.
• W1777564233 cites W2015066175 @default.
• W1777564233 cites W2017073399 @default.
• W1777564233 cites W2021457628 @default.
• W1777564233 cites W2025342494 @default.
• W1777564233 cites W2033950216 @default.
• W1777564233 cites W2040142253 @default.
• W1777564233 cites W2044312503 @default.
• W1777564233 cites W2058839845 @default.
• W1777564233 cites W2062713892 @default.
• W1777564233 cites W2065494505 @default.
• W1777564233 cites W2077309295 @default.
• W1777564233 cites W2077374035 @default.
• W1777564233 cites W2079494240 @default.
• W1777564233 cites W2082117763 @default.
• W1777564233 cites W2086262311 @default.
• W1777564233 cites W2088938008 @default.
• W1777564233 cites W2089921110 @default.
• W1777564233 cites W2092104789 @default.
• W1777564233 cites W2101849511 @default.
• W1777564233 cites W2105516763 @default.
• W1777564233 cites W2108958930 @default.
• W1777564233 cites W2112825652 @default.
• W1777564233 cites W2113911414 @default.
• W1777564233 cites W2115692032 @default.
• W1777564233 cites W2121619780 @default.
• W1777564233 cites W2127150495 @default.
• W1777564233 cites W2146943926 @default.
• W1777564233 cites W2147114673 @default.
• W1777564233 cites W2147746178 @default.
• W1777564233 cites W2152398347 @default.
• W1777564233 cites W2157617883 @default.
• W1777564233 cites W2166529745 @default.
• W1777564233 cites W2171466517 @default.
• W1777564233 cites W2189092666 @default.
• W1777564233 cites W2437298947 @default.
• W1777564233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11522658" @default.
• W1777564233 hasPublicationYear "2001" @default.
• W1777564233 type Work @default.
• W1777564233 sameAs 1777564233 @default.
• W1777564233 citedByCount "67" @default.
• W1777564233 countsByYear W17775642332012 @default.
• W1777564233 countsByYear W17775642332014 @default.
• W1777564233 countsByYear W17775642332015 @default.
• W1777564233 countsByYear W17775642332016 @default.
• W1777564233 countsByYear W17775642332017 @default.
• W1777564233 countsByYear W17775642332018 @default.
• W1777564233 countsByYear W17775642332019 @default.
• W1777564233 countsByYear W17775642332020 @default.
• W1777564233 countsByYear W17775642332021 @default.
• W1777564233 countsByYear W17775642332022 @default.
• W1777564233 crossrefType "journal-article" @default.
• W1777564233 hasAuthorship W1777564233A5020912420 @default.
• W1777564233 hasAuthorship W1777564233A5027476065 @default.
• W1777564233 hasAuthorship W1777564233A5035312473 @default.
• W1777564233 hasAuthorship W1777564233A5043946489 @default.
• W1777564233 hasAuthorship W1777564233A5080654301 @default.
• W1777564233 hasConcept C11882975 @default.
• W1777564233 hasConcept C124320809 @default.
• W1777564233 hasConcept C1491633281 @default.
• W1777564233 hasConcept C16438837 @default.
• W1777564233 hasConcept C184235292 @default.
• W1777564233 hasConcept C185592680 @default.
• W1777564233 hasConcept C199835354 @default.
• W1777564233 hasConcept C28179978 @default.
• W1777564233 hasConcept C29537977 @default.
• W1777564233 hasConcept C502942594 @default.
• W1777564233 hasConcept C55493867 @default.
• W1777564233 hasConcept C62478195 @default.
• W1777564233 hasConcept C75217442 @default.
• W1777564233 hasConcept C82495950 @default.
• W1777564233 hasConcept C86803240 @default.
• W1777564233 hasConcept C94561458 @default.
• W1777564233 hasConcept C95444343 @default.

• next