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- W177767863 abstract "Circadian rhythms, common to most organisms, from bacteria to human, are driven by circadian clocks. These intrinsic timekeeping systems regulate various biochemical, physiological, and behavioral processes with a periodicity of about 24 h, enhancing the efficiency and survival of organisms by allowing them to anticipate and adapt to changing environmental conditions. Mammalian circadian rhythms are generated in pacemaker cells within the suprachiasmatic nuclei (SCN) of the hypothalamus. Pacemakers are composed of molecular oscillators responsible for the control of overt circadian rhythms in the animal’s physiology and behavior. Circadian oscillators are endogenous, cell-autonomous systems that maintain their rhythm even in the absence of external time cues. Importantly, entrainment of the endogenous clock is achieved by specific cues, such as light. It is now well established that peripheral tissues also contain independent oscillators, functionally orchestrated by the central clock within the SCN. The circadian clock is constituted by three conceptual components, the intrinsic pacemaker, the input, and the output pathways. Here we summarize the important molecular and cellular features of the mammalian circadian clock which are critical for the establishment and maintenance of circadian rhythms." @default.
- W177767863 created "2016-06-24" @default.
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- W177767863 date "2009-01-01" @default.
- W177767863 modified "2023-10-16" @default.
- W177767863 title "Transcription Control and the Circadian Clock" @default.
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- W177767863 doi "https://doi.org/10.1016/b978-008045046-9.00194-7" @default.
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