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• W1777773899 abstract "Summary Reasons for performing study There are no peer reviewed, blinded controlled studies regarding the skeletal analgesic efficacy of intramuscularly administered meperidine in horses. Objectives Using an adjustable heart bar shoe model of equine foot pain, the objective of this study was to test the hypothesis that meperidine (pethidine) administered intramuscularly would prove more efficacious in alleviating lameness than a saline placebo. Study design Crossover pharmacodynamic experiment. Methods Eight healthy adult T horoughbred horses randomly underwent weekly i.m. treatments 1 h after lameness induction: saline placebo (1 ml/45 kg bwt) or meperidine hydrochloride (1 mg/kg bwt i.m.). Heart rate ( HR ) and lameness score ( LS ) responses were assessed by a blinded observer every 20 min for 5 h after lameness induction and then hourly through 12 h after treatment. Jugular venous blood samples were obtained at ‐1, 0, 0:05, 1, 2, 4, 6, 8, 10 and 12 h and were subsequently analysed for drug concentrations (lower limit of detection, 1 ng/ml). Repeated measures ANOVA and post hoc T ukey's test were used to identify analgesic effects at a significance level of P<0.05. Results Mean (± s.e.) HR were lower in meperidine trials at 2.3, 3.3 and 3.7 h post administration (P<0.05). Mean LS were lower in meperidine trials at 2.0, 2.3 and 3.3 h post administration (P<0.05). Mean plasma (meperidine) peaked at 227 ± 52 ng/ml at 1 h post administration and decreased to 2.7 ± 0.3 ng/ml at 12 h post administration. In 3 of 8 subjects, plasma (meperidine) was below the lower limit of detection at 12 h after administration. Conclusions Intramuscular meperidine was more effective than the saline placebo but only for 2.0–3.7 h post administration compared with the 8–12 h durations of efficacy reported previously using this same model when horses were treated with nonsteroidal anti‐inflammatory drugs ( NSAIDs ). Meperidine may be a suitable non NSAID alternative analgesic for acute foot pain with efficacy lasting from 2–3 h after a single i.m. dose." @default.
• W1777773899 created "2016-06-24" @default.
• W1777773899 creator A5024825353 @default.
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• W1777773899 date "2013-12-01" @default.
• W1777773899 modified "2023-09-25" @default.
• W1777773899 title "Efficacy of intramuscular meperidine hydrochloride versus placebo in experimental foot lameness in horses" @default.
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• W1777773899 doi "https://doi.org/10.1111/evj.12168" @default.
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• W1777773899 hasPublicationYear "2013" @default.
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