FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1777794322> ?p ?o ?g. }

• W1777794322 endingPage "41" @default.
• W1777794322 startingPage "2438" @default.
• W1777794322 abstract "Feeding of raw soya flour or other trypsin inhibitors such as camostate is a well-established method for promoting growth of (pre)neoplastic foci induced in the exocrine pancreas of rats by azaserine. The effect of trypsin inhibitors is thought to be mediated through an increased release of cholecystokinin. Using the specific cholecystokinin receptor antagonist lorglumide (CR-1409), we performed a 16-wk study to investigate the potential of this drug in inhibiting growth of putative preneoplastic foci and to determine whether and to what extent cholecystokinin is responsible for the effect of trypsin inhibitors on pancreatic growth. After initiation with 30 mg/kg of azaserine at 19 days of age, six groups of 15 rats each received one of the following treatments: camostate, cholecystokinin-8, or gelatin control, either or not in combination with CR-1409, once daily, 3 days wk for 16 wk. Plasma cholecystokinin levels, measured 30 min after the stimulus, were similar after camostate and cholecystokinin octapeptide administration. After 16 wk the pancreata were removed, weighted, and quantitatively analyzed for the number and size of putative preneoplastic foci by light microscopy. Both camostate and cholecystokinin octapeptide stimulated pancreatic growth and development of acidophilic putative preneoplastic foci, whereas growth of basophilic putative preneoplastic foci was inhibited by camostate but stimulated by cholecystokinin. CR-1409 almost completely abolished the effect of cholecystokinin and was found to cause a significant decrease in the effects of camostate. It is concluded that (a) cholecystokinin plays a significant role in camostate-stimulated growth of acidophilic putative preneoplastic foci in rat pancreas and (b) CR-1409 inhibits growth of putative preneoplastic foci induced in rat pancreas by azaserine and hence may be of potential value for the treatment of pancreatic cancer in humans." @default.
• W1777794322 created "2016-06-24" @default.
• W1777794322 creator A5016313083 @default.
• W1777794322 creator A5027693297 @default.
• W1777794322 creator A5055579821 @default.
• W1777794322 creator A5059553050 @default.
• W1777794322 creator A5073060671 @default.
• W1777794322 creator A5090077696 @default.
• W1777794322 date "1989-05-01" @default.
• W1777794322 modified "2023-09-27" @default.
• W1777794322 title "Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas." @default.
• W1777794322 cites W1539182109 @default.
• W1777794322 cites W1588330773 @default.
• W1777794322 cites W1646340036 @default.
• W1777794322 cites W1756052478 @default.
• W1777794322 cites W1842060488 @default.
• W1777794322 cites W1982492732 @default.
• W1777794322 cites W2015234075 @default.
• W1777794322 cites W2033724612 @default.
• W1777794322 cites W2047683507 @default.
• W1777794322 cites W2070028718 @default.
• W1777794322 cites W2071983363 @default.
• W1777794322 cites W2092653589 @default.
• W1777794322 cites W2272694962 @default.
• W1777794322 cites W2290169940 @default.
• W1777794322 cites W2333999038 @default.
• W1777794322 cites W2394988465 @default.
• W1777794322 cites W2409820058 @default.
• W1777794322 cites W2418154393 @default.
• W1777794322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2706631" @default.
• W1777794322 hasPublicationYear "1989" @default.
• W1777794322 type Work @default.
• W1777794322 sameAs 1777794322 @default.
• W1777794322 citedByCount "17" @default.
• W1777794322 crossrefType "journal-article" @default.
• W1777794322 hasAuthorship W1777794322A5016313083 @default.
• W1777794322 hasAuthorship W1777794322A5027693297 @default.
• W1777794322 hasAuthorship W1777794322A5055579821 @default.
• W1777794322 hasAuthorship W1777794322A5059553050 @default.
• W1777794322 hasAuthorship W1777794322A5073060671 @default.
• W1777794322 hasAuthorship W1777794322A5090077696 @default.
• W1777794322 hasConcept C126322002 @default.
• W1777794322 hasConcept C134018914 @default.
• W1777794322 hasConcept C170493617 @default.
• W1777794322 hasConcept C181199279 @default.
• W1777794322 hasConcept C2776079162 @default.
• W1777794322 hasConcept C2776309477 @default.
• W1777794322 hasConcept C2776351012 @default.
• W1777794322 hasConcept C2776885963 @default.
• W1777794322 hasConcept C2777593968 @default.
• W1777794322 hasConcept C2777951760 @default.
• W1777794322 hasConcept C2778764654 @default.
• W1777794322 hasConcept C2779349466 @default.
• W1777794322 hasConcept C2780340462 @default.
• W1777794322 hasConcept C32110497 @default.
• W1777794322 hasConcept C515207424 @default.
• W1777794322 hasConcept C55493867 @default.
• W1777794322 hasConcept C56191518 @default.
• W1777794322 hasConcept C71315377 @default.
• W1777794322 hasConcept C71924100 @default.
• W1777794322 hasConcept C86803240 @default.
• W1777794322 hasConceptScore W1777794322C126322002 @default.
• W1777794322 hasConceptScore W1777794322C134018914 @default.
• W1777794322 hasConceptScore W1777794322C170493617 @default.
• W1777794322 hasConceptScore W1777794322C181199279 @default.
• W1777794322 hasConceptScore W1777794322C2776079162 @default.
• W1777794322 hasConceptScore W1777794322C2776309477 @default.
• W1777794322 hasConceptScore W1777794322C2776351012 @default.
• W1777794322 hasConceptScore W1777794322C2776885963 @default.
• W1777794322 hasConceptScore W1777794322C2777593968 @default.
• W1777794322 hasConceptScore W1777794322C2777951760 @default.
• W1777794322 hasConceptScore W1777794322C2778764654 @default.
• W1777794322 hasConceptScore W1777794322C2779349466 @default.
• W1777794322 hasConceptScore W1777794322C2780340462 @default.
• W1777794322 hasConceptScore W1777794322C32110497 @default.
• W1777794322 hasConceptScore W1777794322C515207424 @default.
• W1777794322 hasConceptScore W1777794322C55493867 @default.
• W1777794322 hasConceptScore W1777794322C56191518 @default.
• W1777794322 hasConceptScore W1777794322C71315377 @default.
• W1777794322 hasConceptScore W1777794322C71924100 @default.
• W1777794322 hasConceptScore W1777794322C86803240 @default.
• W1777794322 hasIssue "9" @default.
• W1777794322 hasLocation W17777943221 @default.
• W1777794322 hasOpenAccess W1777794322 @default.
• W1777794322 hasPrimaryLocation W17777943221 @default.
• W1777794322 hasRelatedWork W1646340036 @default.
• W1777794322 hasRelatedWork W1777794322 @default.
• W1777794322 hasRelatedWork W1982594208 @default.
• W1777794322 hasRelatedWork W1993973335 @default.
• W1777794322 hasRelatedWork W2009742740 @default.
• W1777794322 hasRelatedWork W2031272904 @default.
• W1777794322 hasRelatedWork W2048534045 @default.
• W1777794322 hasRelatedWork W2079059552 @default.
• W1777794322 hasRelatedWork W2081465146 @default.
• W1777794322 hasRelatedWork W2089769840 @default.
• W1777794322 hasVolume "49" @default.
• W1777794322 isParatext "false" @default.
• W1777794322 isRetracted "false" @default.

• next