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• W177788487 abstract "There are at least four possible ways in which inhibitors of cyclin-dependent kinases (CDKs) might regulate cell cycle progression (Fig. 1). First, they might determine the duration of G1 phase by setting a threshold above which G1 CDK activity must accumulate before initiation of S-phase. In this threshold role, steady-state levels of CDK inhibitors (CKIs) counteract the temporal accumulation of G1 cyclin/CDK complexes. Second, they might act as checkpoints inducing cell cycle arrest transiently when genomic fidelity is threatened. Chromosome damage or inappropriate segregation of chromosomes may induce cell cycle arrest and initiate DNA repair mechanisms or apoptotic programs. Third, CKIs might allow expedient withdrawal of cells from the cell cycle and a concomitant change in cell fate. In some cases, CKIs might not only regulate the withdrawal from the cell cycle but also affect lineage-specific functions. Fourth, they might function as a gatekeeper of quiescence, keeping the GO cell from inappropriately resuming proliferation. In some cases, tumors arise from well differentiated and non-mitotic cells that inexplicably return to the cell cycle. Over the last 5 years, biochemical, cellular, and molecular analyses of CKIs have combined with genetic analysis of mutant mice deficient in each CKI to address these possible functions. Our current knowledge of the role of CKI in these decisions and speculations about their roles in developmentally regulated cell cycles are discussed below." @default.
• W177788487 created "2016-06-24" @default.
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• W177788487 date "1998-01-01" @default.
• W177788487 modified "2023-09-23" @default.
• W177788487 title "Regulation of the cell cycle by CDK inhibitors" @default.
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• W177788487 cites W1969385456 @default.
• W177788487 cites W1971245466 @default.
• W177788487 cites W1975324295 @default.
• W177788487 cites W1977299280 @default.
• W177788487 cites W1979781336 @default.
• W177788487 cites W1982768428 @default.
• W177788487 cites W1990743609 @default.
• W177788487 cites W1996413533 @default.
• W177788487 cites W1997643531 @default.
• W177788487 cites W2003282728 @default.
• W177788487 cites W2003907692 @default.
• W177788487 cites W2007772649 @default.
• W177788487 cites W2009277631 @default.
• W177788487 cites W2015066175 @default.
• W177788487 cites W2015519364 @default.
• W177788487 cites W2017091696 @default.
• W177788487 cites W2018697286 @default.
• W177788487 cites W2029350186 @default.
• W177788487 cites W2030231219 @default.
• W177788487 cites W2033156691 @default.
• W177788487 cites W2036817346 @default.
• W177788487 cites W2038144609 @default.
• W177788487 cites W2040461990 @default.
• W177788487 cites W2041024018 @default.
• W177788487 cites W2041573061 @default.
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• W177788487 cites W2047460928 @default.
• W177788487 cites W2048743150 @default.
• W177788487 cites W2049020574 @default.
• W177788487 cites W2049085719 @default.
• W177788487 cites W2052165202 @default.
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• W177788487 cites W2055322640 @default.
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• W177788487 cites W2070061120 @default.
• W177788487 cites W2070811212 @default.
• W177788487 cites W2073166133 @default.
• W177788487 cites W2076273397 @default.
• W177788487 cites W2078690152 @default.
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• W177788487 cites W2084891010 @default.
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• W177788487 cites W2088966640 @default.
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• W177788487 cites W2128705810 @default.
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• W177788487 cites W2143162998 @default.
• W177788487 cites W2144942522 @default.
• W177788487 cites W2145281774 @default.
• W177788487 cites W2146636701 @default.
• W177788487 cites W2151559596 @default.
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• W177788487 cites W2157033538 @default.
• W177788487 cites W2161378573 @default.
• W177788487 cites W2166529745 @default.
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• W177788487 doi "https://doi.org/10.1007/978-3-540-69686-5_5" @default.
• W177788487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9670321" @default.
• W177788487 hasPublicationYear "1998" @default.
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