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- W1777887250 endingPage "505" @default.
- W1777887250 startingPage "453" @default.
- W1777887250 abstract "This chapter discusses the mechanisms by which nicotinamide adenine dinucleotide (NAD)-dependent enzymes catalyze chemistry at two sites in the coenzyme molecule. The dehydrogenase-catalyzed redox chemistry that occurs at the 4-position of the nicotinamide ring is discussed in the chapter, and the cleavage of the C-1′-N ribosyl linkage catalyzed by a variety of NAD + glycohydrolases and ADP-ribosyltransferases is assessed. The discussion concentrates on the underlying chemistry and the various means by which these enzymes promote catalysis. The mechanism of dehydrogenases is intimately related to the chemistry of the pyridine coenzymes. Emphasis is on dehydrogenases that catalyze the oxidation of alcohol functionalities, with specific emphasis on horse liver and yeast alcohol dehydrogenases and α-hydroxy-acid dehydrogenases, such as lactate dehydrogenase. The impact of the chemical and mechanistic constraints of the reactions of models for the evolution of dehydrogenase function is also discussed." @default.
- W1777887250 created "2016-06-24" @default.
- W1777887250 creator A5032908862 @default.
- W1777887250 creator A5076426461 @default.
- W1777887250 date "1992-01-01" @default.
- W1777887250 modified "2023-10-15" @default.
- W1777887250 title "10 Mechanism of NAD-Dependent Enzymes" @default.
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