FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1777950990> ?p ?o ?g. }

• W1777950990 endingPage "852" @default.
• W1777950990 startingPage "844" @default.
• W1777950990 abstract "Summary One of the most prominent changes during T‐cell aging in humans is the accumulation of CD28 null T cells, mainly CD8+ and also CD4+ T cells. Enhancing the functional properties of these cells may be important as they provide an antigen‐specific defense against chronic infections. Recent studies have shown that IL‐15 does in fact play an appreciable role in CD4 memory T cells under physiological conditions. We found that treatment with IL‐15 increased the frequency of elderly CD4+CD28 null T cells by the preferential proliferation of these cells compared to CD4+CD28+ T cells. IL‐15 induced an activated phenotype in CD4+CD28 null T cells. Although the surface expression of IL‐15R α‐chain was not increased, the transcription factor STAT‐5 was preferentially activated. IL‐15 augmented the cytotoxic properties of CD4+CD28 null T cells by increasing both the mRNA transcription and storage of granzyme B and perforin for the cytolytic effector functions. Moreover, pretreatment of CD4+CD28 null T cells with IL‐15 displayed a synergistic effect on the IFN‐γ production in CMV‐specific responses, which was not observed in CD4+CD28+ T cells. IL‐15 could play a role enhancing the effector response of CD4+CD28 null T cells against their specific chronic antigens." @default.
• W1777950990 created "2016-06-24" @default.
• W1777950990 creator A5017625454 @default.
• W1777950990 creator A5027999501 @default.
• W1777950990 creator A5032408537 @default.
• W1777950990 creator A5034662201 @default.
• W1777950990 creator A5046557645 @default.
• W1777950990 creator A5073116857 @default.
• W1777950990 creator A5076951538 @default.
• W1777950990 date "2011-06-27" @default.
• W1777950990 modified "2023-10-17" @default.
• W1777950990 title "IL-15 preferentially enhances functional properties and antigen-specific responses of CD4+CD28^nullcompared to CD4+CD28+ T cells" @default.
• W1777950990 cites W1495069682 @default.
• W1777950990 cites W1576064052 @default.
• W1777950990 cites W1586815424 @default.
• W1777950990 cites W1646277151 @default.
• W1777950990 cites W1913005460 @default.
• W1777950990 cites W1963987860 @default.
• W1777950990 cites W1964079370 @default.
• W1777950990 cites W1976789091 @default.
• W1777950990 cites W1981480494 @default.
• W1777950990 cites W1989727528 @default.
• W1777950990 cites W1990331651 @default.
• W1777950990 cites W1990863238 @default.
• W1777950990 cites W1994111355 @default.
• W1777950990 cites W1997196319 @default.
• W1777950990 cites W2006027051 @default.
• W1777950990 cites W2008265716 @default.
• W1777950990 cites W2014912378 @default.
• W1777950990 cites W2035121127 @default.
• W1777950990 cites W2036610484 @default.
• W1777950990 cites W2043344627 @default.
• W1777950990 cites W2047102094 @default.
• W1777950990 cites W2049192141 @default.
• W1777950990 cites W2053988604 @default.
• W1777950990 cites W2056376302 @default.
• W1777950990 cites W2061168748 @default.
• W1777950990 cites W2072857434 @default.
• W1777950990 cites W2074275613 @default.
• W1777950990 cites W2075372159 @default.
• W1777950990 cites W2085921835 @default.
• W1777950990 cites W2094018334 @default.
• W1777950990 cites W2101937163 @default.
• W1777950990 cites W2103059589 @default.
• W1777950990 cites W2120659687 @default.
• W1777950990 cites W2127576962 @default.
• W1777950990 cites W2127708226 @default.
• W1777950990 cites W2133997960 @default.
• W1777950990 cites W2139285775 @default.
• W1777950990 cites W2142170111 @default.
• W1777950990 cites W2142285575 @default.
• W1777950990 cites W2149204478 @default.
• W1777950990 cites W2150595242 @default.
• W1777950990 cites W2150895619 @default.
• W1777950990 cites W2153127076 @default.
• W1777950990 cites W2153680933 @default.
• W1777950990 cites W2153919530 @default.
• W1777950990 cites W2155177282 @default.
• W1777950990 cites W2160352261 @default.
• W1777950990 cites W2164514428 @default.
• W1777950990 cites W2171953655 @default.
• W1777950990 cites W4230676991 @default.
• W1777950990 doi "https://doi.org/10.1111/j.1474-9726.2011.00725.x" @default.
• W1777950990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21635686" @default.
• W1777950990 hasPublicationYear "2011" @default.
• W1777950990 type Work @default.
• W1777950990 sameAs 1777950990 @default.
• W1777950990 citedByCount "25" @default.
• W1777950990 countsByYear W17779509902012 @default.
• W1777950990 countsByYear W17779509902013 @default.
• W1777950990 countsByYear W17779509902015 @default.
• W1777950990 countsByYear W17779509902016 @default.
• W1777950990 countsByYear W17779509902017 @default.
• W1777950990 countsByYear W17779509902018 @default.
• W1777950990 countsByYear W17779509902020 @default.
• W1777950990 countsByYear W17779509902021 @default.
• W1777950990 countsByYear W17779509902022 @default.
• W1777950990 crossrefType "journal-article" @default.
• W1777950990 hasAuthorship W1777950990A5017625454 @default.
• W1777950990 hasAuthorship W1777950990A5027999501 @default.
• W1777950990 hasAuthorship W1777950990A5032408537 @default.
• W1777950990 hasAuthorship W1777950990A5034662201 @default.
• W1777950990 hasAuthorship W1777950990A5046557645 @default.
• W1777950990 hasAuthorship W1777950990A5073116857 @default.
• W1777950990 hasAuthorship W1777950990A5076951538 @default.
• W1777950990 hasBestOaLocation W17779509902 @default.
• W1777950990 hasConcept C129374314 @default.
• W1777950990 hasConcept C147483822 @default.
• W1777950990 hasConcept C148125776 @default.
• W1777950990 hasConcept C153911025 @default.
• W1777950990 hasConcept C154317977 @default.
• W1777950990 hasConcept C167672396 @default.
• W1777950990 hasConcept C202751555 @default.
• W1777950990 hasConcept C203014093 @default.
• W1777950990 hasConcept C2776062744 @default.
• W1777950990 hasConcept C55493867 @default.
• W1777950990 hasConcept C86803240 @default.
• W1777950990 hasConcept C95444343 @default.

• next