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• W1777983468 abstract "Experimental observations on cyclic splitting and bending by a flagellar doublet pair are modeled using forces obtained from a model for dynein mechanochemistry, based on ideas introduced by Andrew Huxley and Terrill Hill and extended previously for modeling flagellar movements. The new feature is elastic attachment of dynein to the A doublet, which allows movement perpendicular to the A doublet and provides adhesive force that can strain attached dyneins. This additional strain influences the kinetics of dynein attachment and detachment. Computations using this dynein model demonstrate that very simple and realistic ideas about dynein mechanochemistry are sufficient for explaining the separation and reattachment seen experimentally with flagellar doublet pairs. Additional simulations were performed after adding a super-adhesion elasticity. This elastic component is intended to mimic interdoublet connections, normally present in an intact axoneme, that would prevent visible splitting but allow sufficient separation to cause dynein detachment and cessation of shear force generation. This is the situation envisioned by Lindemann's geometric clutch hypothesis for control of dynein function in flagella and cilia. The simulations show abrupt disengagement of the clutch at one end of a bend, and abrupt reengagement of the clutch at the other end of a bend, ensuring that active sliding is only operating where it will cause bend propagation from base to tip." @default.
• W1777983468 created "2016-06-24" @default.
• W1777983468 creator A5084691151 @default.
• W1777983468 date "2014-03-26" @default.
• W1777983468 modified "2023-09-23" @default.
• W1777983468 title "Computer simulation of flagellar movement X: Doublet pair splitting and bend propagation modeled using stochastic dynein kinetics" @default.
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• W1777983468 doi "https://doi.org/10.1002/cm.21168" @default.
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