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• W1777985478 abstract "The mammalian genome contains on the order of a million enhancer-like regions that are required to establish the identities and functions of specific cell types. Here, we review recent studies in immune cells that have provided insight into the mechanisms that selectively activate certain enhancers in response to cell lineage and environmental signals. We describe a working model wherein distinct classes of transcription factors define the repertoire of active enhancers in macrophages through collaborative and hierarchical interactions, and discuss important challenges to this model, specifically providing examples from T cells. We conclude by discussing the use of natural genetic variation as a powerful approach for decoding transcription factor combinations that play dominant roles in establishing the enhancer landscapes, and the potential that these insights have for advancing our understanding of the molecular causes of human disease." @default.
• W1777985478 created "2016-06-24" @default.
• W1777985478 creator A5044074995 @default.
• W1777985478 creator A5044844190 @default.
• W1777985478 creator A5088744297 @default.
• W1777985478 creator A5090232554 @default.
• W1777985478 date "2015-09-01" @default.
• W1777985478 modified "2023-10-17" @default.
• W1777985478 title "Exploiting genomics and natural genetic variation to decode macrophage enhancers" @default.
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