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- W1779084429 abstract "Background Visceral fat tissue is the source of many importantsubstances such as: resistin, tumor necrosis factor alpha (TNF-a) and many others. The aims of the studywere to: 1. Estimate the concentrations of resistin, insulin, soluble receptors for TNF-a among patients with metabolicsyndrome; 2. Assess insulin resistance according to HOMA index and estimate correlations between it andhypertension; 3. Investigate correlations between choosenadipocytokines, anthropometric parameters, insulin andhypertension. Material and methods 85 patients with metabolic syndromewere investigated. Control group was 20 healthy volunteers.In both populations anthropological parameters such asbody mass index (BMI), waist–hip ratio (WHR), were measured,concentration of resistin, insulin and soluble receptors for TNF-a in the blood had been also assessed. Results had shown increased serum levels of resistin andSTNFR1 and STNFR2. Insulin resistance, present in investigatedgroup, was final effect of hyperresistinemia, elevatedconcentrations of STNFR1 and STNFR2. Results have also revealed connection between resistin, and solublereceptors for TNF-a, insulin resistance and values of blood pressure. Resistinemia and concentration ofSTNFR1 and STNFR2 correlated with values of blood pressure. It may suggest that adipocytokines can induceincrease of systolic and diastolic blood pressure. Conclusions 1. Patients with metabolic syndrome arecharacterized by many disorders connected with each other, such as hyperresistinemia and elevated levels ofsoluble receptors for TNF-a. 2. Insulin resistance presents in metabolic syndrome, correlates with chosenanthropometrics parameters and hypertension. 3. Concentrationof adipocytokines modulate insulin resistance; resistin, STNFR1 and STNFR2 increase it; they also canincrease the levels of blood pressure." @default.
- W1779084429 created "2016-06-24" @default.
- W1779084429 creator A5035306429 @default.
- W1779084429 date "2011-01-01" @default.
- W1779084429 modified "2023-09-26" @default.
- W1779084429 title "Czy produkty wisceralnej tkanki tłuszczowej — rezystyna i TNF-a — modulują wartości ciśnienia tętniczego?" @default.
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