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- W1779664314 abstract "Salmonella enterica serovar Enteritidis (S. Enteritidis) is a major food-borne pathogen. From a transposon insertion mutant library created previously using S. Enteritidis 10/02, one of the mutants was identified to have a 50% lethal dose (LD(50) ) at least 100 times that of the parental strain in young chicks, with an attenuation in a poorly studied gene encoding a component of pyruvate dehydrogenase, namely the aceE gene. Evaluation of the in vitro virulence characteristics of the ΔaceE∷kan mutant revealed that it was less able to invade epithelial cells, less resistant to reactive oxygen intermediate, less able to survive within a chicken macrophage cell line and had a retarded growth rate compared with the parental strain. Young chicks vaccinated with 2 × 10(9) CFU of the ΔaceE∷kan mutant were protected from the subsequent challenge of the parental strain, with the mutant colonized in the liver and spleen in a shorter time than the group infected with the parental strain. In addition, compared with the parental strain, the ΔaceE∷kan mutant did not cause persistent eggshell contamination of vaccinated hens." @default.
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- W1779664314 date "2011-10-01" @default.
- W1779664314 modified "2023-09-28" @default.
- W1779664314 title "Deletion of the<i>aceE</i>gene (encoding a component of pyruvate dehydrogenase) attenuates<i>Salmonella enterica</i>serovar Enteritidis" @default.
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- W1779664314 doi "https://doi.org/10.1111/j.1574-695x.2011.00834.x" @default.
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