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• W177979381 abstract "d-α-Tocopherol decreases proliferation of vascular smooth muscle cells at physiological concentrations. Cell type specificity and mitogen specificity (maximal inhibition with PDGF-BB or LDL, minimal with lysophosphatidic acid) are observed. A d-α-tocopherol inhibition target has been found at the level of protein kinase C. The inhibition is not due to a direct interaction d-α-tocopherol/ protein kinase C but presumably to a block of protein kinase C activation by post-translational modifications. PMA-induced AP-1 activation is also inhibited by d-α-tocopherol. A second d-α-tocopherol target has been found between protein kinase C and AP-1, the latter becoming activated by d-α-tocopherol in non stimulated cells as well as under conditions of protein kinase C inhibition or down regulation. The d-α-tocopherol analogue d-s-tocopherol, provided with similar antioxidant properties, is not inhibitory for protein kinase C, AP-1 activation or proliferation. It is concluded that d-α-tocopherol acts at a cellular level by controlling the signal transduction pathway by a non-antioxidant mechanism." @default.
• W177979381 created "2016-06-24" @default.
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• W177979381 date "1995-01-01" @default.
• W177979381 modified "2023-09-27" @default.
• W177979381 title "Vascular smooth muscle cell proliferation is controlled by d-α-tocopherol at the level of protein kinase C and of the transcription factor AP-1" @default.
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• W177979381 doi "https://doi.org/10.1007/978-3-0348-7337-6_7" @default.
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