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- W178015100 abstract "Abstract Interleukin-34 (IL-34) has a similar function with M-CSF via M-CSF receptor, c-fms, which also involves in RANKL-osteoclastogenesis. In this study, we found that IL-34 was up-regulated in the synovial fluid of RA patients with diagnostic positive rheumatoid factors. IL-34 production was much higher in the synovial fibroblast of RA patients than in that of OA patients and which was enhanced by TNFa stimulation. The expression of IL-34 mRNA and protein in synovial fibroblasts of RA patient after TNFa stimulation were determined using real-time PCR and western blot. Interestingly, TNFa induced IL-34 expression but not M-CSF dependently on NF-kB activity. The conditioned medium of synovial fibroblasts of RA patient cultured with TNFa led to chemotactic migration of human monocytes, and which was blocked by anti-IL-34 antibodies. Moreover, blocking IL-34 activity hindered the RNAKL-induced osteoclastogenesis in same conditioned medium. These results demonstrate that the increase of biologically active IL-34 in the RA synovium induces the chemotactic migration of osteoclast precursor cells and subsequently supports osteoclastogenesis in the inflammed synovium. Together, the differential regulation of IL-34 and M-CSF expression levels by TNFa further implies discrete role of IL-34 in the inflammatory condition involving RA pathogenesis." @default.
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- W178015100 date "2011-04-01" @default.
- W178015100 modified "2023-09-27" @default.
- W178015100 title "IL-34 produced by human synovial fibroblast in rheumatoid arthritis supports osteoclastogenesis (117.17)" @default.
- W178015100 doi "https://doi.org/10.4049/jimmunol.186.supp.117.17" @default.
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