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- W1780286233 abstract "Genetics and pathology have proven to be an effective combination to identify an evolving and deepening landscape of pathways and potential therapeutic targets in neurodegenerative diseases. Initially this landscape appeared to be populated with distinct therapeutic targets but with potentially overlapping mechanisms in each neurodegenerative disease. Our understanding has expanded to recognize that multiple pathologies are common in neurodegenerative disease, and that there is considerable overlap in pathways and targets driving neurodegenerative diseases. This potentially opens the way for future treatments to be indicated by tissue pathology and genetic basis rather than clinical phenotype. The potential to treat neurodegenerative disease by addressing underlying pathophysiology is still in the early days and challenges remain, especially the likely need to address pathologies early in disease. This will require redefinition of diagnosis and the tools to enable earlier diagnosis." @default.
- W1780286233 created "2016-06-24" @default.
- W1780286233 creator A5018504427 @default.
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- W1780286233 date "2015-09-29" @default.
- W1780286233 modified "2023-10-14" @default.
- W1780286233 title "Promising Targets for the Treatment of Neurodegenerative Diseases" @default.
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- W1780286233 doi "https://doi.org/10.1002/cpt.195" @default.
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