FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1780329197> ?p ?o ?g. }

• W1780329197 endingPage "1664" @default.
• W1780329197 startingPage "1652" @default.
• W1780329197 abstract "BACKGROUND AND PURPOSE Pharmacological interventions aimed at restoring the endocannabinoid system functionality have been proposed as potential tools in the treatment of schizophrenia. Based on our previous results suggesting a potential antipsychotic-like profile of the CB1 receptor inverse agonist/antagonist, AM251, here we further investigated the effect of chronic AM251 administration on the alteration of the sensorimotor gating functions and endocannabinoid levels induced by isolation rearing in rats. EXPERIMENTAL APPROACH Using the post-weaning social isolation rearing model, we studied its influence on sensorimotor gating functions through the PPI paradigm. The presence of alterations in the endocannabinoid levels as well as in dopamine and glutamate receptor densities was explored in specific brain regions following isolation rearing. The effect of chronic AM251 administration on PPI response and the associated biochemical alterations was assessed. KEY RESULTS The disrupted PPI response in isolation-reared rats was paralleled by significant alterations in 2-AG content and dopamine and glutamate receptor densities in specific brain regions. Chronic AM251 completely restored normal PPI response in isolated rats. This behavioural recovery was paralleled by the normalization of 2-AG levels in all the brain areas analysed. Furthermore, AM251 partially antagonized isolation-induced changes in dopamine and glutamate receptors. CONCLUSIONS AND IMPLICATIONS These results demonstrate the efficacy of chronic AM251 treatment in the recovery of isolation-induced disruption of PPI. Moreover, AM251 counteracted the imbalances in the endocannabinoid content, specifically 2-AG levels, and partially reversed the alterations in dopamine and glutamate systems associated with the disrupted behaviour. Together, these findings support the potential antipsychotic-like activity of CB1 receptor blockade. LINKED ARTICLES This article is part of a themed section on Cannabinoids. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2012.167.issue-8" @default.
• W1780329197 created "2016-06-24" @default.
• W1780329197 creator A5007484138 @default.
• W1780329197 creator A5018060120 @default.
• W1780329197 creator A5022816206 @default.
• W1780329197 creator A5029512095 @default.
• W1780329197 creator A5056784492 @default.
• W1780329197 creator A5068288757 @default.
• W1780329197 creator A5076289110 @default.
• W1780329197 creator A5088798211 @default.
• W1780329197 date "2012-11-29" @default.
• W1780329197 modified "2023-10-18" @default.
• W1780329197 title "Chronic blockade of CB₁receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation" @default.
• W1780329197 cites W1593555249 @default.
• W1780329197 cites W1916800927 @default.
• W1780329197 cites W1965634122 @default.
• W1780329197 cites W1969966028 @default.
• W1780329197 cites W1970052685 @default.
• W1780329197 cites W1973952134 @default.
• W1780329197 cites W1975061094 @default.
• W1780329197 cites W1982291289 @default.
• W1780329197 cites W1985496935 @default.
• W1780329197 cites W1994045297 @default.
• W1780329197 cites W2005756201 @default.
• W1780329197 cites W2005972779 @default.
• W1780329197 cites W2019243277 @default.
• W1780329197 cites W2019342778 @default.
• W1780329197 cites W2021275952 @default.
• W1780329197 cites W2028577345 @default.
• W1780329197 cites W2029277771 @default.
• W1780329197 cites W2030623240 @default.
• W1780329197 cites W2035892231 @default.
• W1780329197 cites W2040080264 @default.
• W1780329197 cites W2040151970 @default.
• W1780329197 cites W2042453545 @default.
• W1780329197 cites W2042587343 @default.
• W1780329197 cites W2046827837 @default.
• W1780329197 cites W2053232417 @default.
• W1780329197 cites W2054167352 @default.
• W1780329197 cites W2060377735 @default.
• W1780329197 cites W2065432160 @default.
• W1780329197 cites W2072511085 @default.
• W1780329197 cites W2074867313 @default.
• W1780329197 cites W2077767624 @default.
• W1780329197 cites W2079893977 @default.
• W1780329197 cites W2084070896 @default.
• W1780329197 cites W2096003899 @default.
• W1780329197 cites W2102040370 @default.
• W1780329197 cites W2108792509 @default.
• W1780329197 cites W2113325262 @default.
• W1780329197 cites W2117296341 @default.
• W1780329197 cites W2135031097 @default.
• W1780329197 cites W2138685334 @default.
• W1780329197 cites W2146738944 @default.
• W1780329197 cites W2150629711 @default.
• W1780329197 cites W2151070269 @default.
• W1780329197 cites W2153405622 @default.
• W1780329197 cites W2162906523 @default.
• W1780329197 cites W2169269177 @default.
• W1780329197 cites W2327641061 @default.
• W1780329197 cites W9766445 @default.
• W1780329197 doi "https://doi.org/10.1111/j.1476-5381.2012.02095.x" @default.
• W1780329197 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3525868" @default.
• W1780329197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22762735" @default.
• W1780329197 hasPublicationYear "2012" @default.
• W1780329197 type Work @default.
• W1780329197 sameAs 1780329197 @default.
• W1780329197 citedByCount "12" @default.
• W1780329197 countsByYear W17803291972012 @default.
• W1780329197 countsByYear W17803291972013 @default.
• W1780329197 countsByYear W17803291972014 @default.
• W1780329197 countsByYear W17803291972015 @default.
• W1780329197 countsByYear W17803291972016 @default.
• W1780329197 countsByYear W17803291972017 @default.
• W1780329197 countsByYear W17803291972019 @default.
• W1780329197 countsByYear W17803291972020 @default.
• W1780329197 countsByYear W17803291972021 @default.
• W1780329197 countsByYear W17803291972022 @default.
• W1780329197 crossrefType "journal-article" @default.
• W1780329197 hasAuthorship W1780329197A5007484138 @default.
• W1780329197 hasAuthorship W1780329197A5018060120 @default.
• W1780329197 hasAuthorship W1780329197A5022816206 @default.
• W1780329197 hasAuthorship W1780329197A5029512095 @default.
• W1780329197 hasAuthorship W1780329197A5056784492 @default.
• W1780329197 hasAuthorship W1780329197A5068288757 @default.
• W1780329197 hasAuthorship W1780329197A5076289110 @default.
• W1780329197 hasAuthorship W1780329197A5088798211 @default.
• W1780329197 hasBestOaLocation W17803291972 @default.
• W1780329197 hasConcept C118552586 @default.
• W1780329197 hasConcept C126322002 @default.
• W1780329197 hasConcept C134018914 @default.
• W1780329197 hasConcept C141421786 @default.
• W1780329197 hasConcept C148001335 @default.
• W1780329197 hasConcept C170493617 @default.
• W1780329197 hasConcept C25876315 @default.
• W1780329197 hasConcept C2776158853 @default.
• W1780329197 hasConcept C2776412080 @default.
• W1780329197 hasConcept C2778938600 @default.

• next