FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1780456323> ?p ?o ?g. }

• W1780456323 endingPage "3382" @default.
• W1780456323 startingPage "3376" @default.
• W1780456323 abstract "ABSTRACT The extent to which the mammalian host is capable of enzymatic degradation and detoxification of bacterial lipopolysaccharides (LPS) is still unknown. Partial deacylation of LPS by the enzyme acyloxyacyl hydrolase (AOAH) provides such a mechanism, but its participation in the disposal of LPS under physiological conditions has not been established. In this study, deacylation of isolated radiolabeled LPS by both cellular and extracellular components of a sterile inflammatory peritoneal exudate elicited in rabbits was examined ex vivo. AOAH-like activity, tested under artificial conditions (pH 5.4, 0.1% Triton X-100), was evident in all components of the exudate (mononuclear cells [MNC] > polymorphonuclear leukocytes [PMN] > inflammatory [ascitic] fluid [AF]). Under more physiological conditions, in a defined medium containing purified LPS-binding protein, the LPS-deacylating activity of MNC greatly exceeded that of PMN. In AF, MNC (but not PMN) also produced rapid and extensive CD14-dependent LPS deacylation. Under these conditions, almost all MNC-associated LPS underwent deacylation within 1 h, a rate greatly exceeding that previously found in any cell type. The remaining extracellular LPS was more slowly subject to CD14-independent deacylation in AF. Quantitative analysis showed a comparable release of laurate and myristate but no release of 3-hydroxymyristate, consistent with an AOAH-like activity. These findings suggest a major role for CD14 + MNC and a secondary role for AF in the deacylation of cell-free LPS at extravascular inflammatory sites." @default.
• W1780456323 created "2016-06-24" @default.
• W1780456323 creator A5004514532 @default.
• W1780456323 creator A5007027790 @default.
• W1780456323 creator A5023095988 @default.
• W1780456323 creator A5080303179 @default.
• W1780456323 creator A5086002028 @default.
• W1780456323 date "1999-07-01" @default.
• W1780456323 modified "2023-10-16" @default.
• W1780456323 title "Deacylation of Purified Lipopolysaccharides by Cellular and Extracellular Components of a Sterile Rabbit Peritoneal Inflammatory Exudate" @default.
• W1780456323 cites W1520507377 @default.
• W1780456323 cites W1527021271 @default.
• W1780456323 cites W1528453845 @default.
• W1780456323 cites W1543949372 @default.
• W1780456323 cites W1602150205 @default.
• W1780456323 cites W1616283658 @default.
• W1780456323 cites W1848812703 @default.
• W1780456323 cites W1878695667 @default.
• W1780456323 cites W1929138646 @default.
• W1780456323 cites W1967501462 @default.
• W1780456323 cites W1969598156 @default.
• W1780456323 cites W1992809091 @default.
• W1780456323 cites W2006697711 @default.
• W1780456323 cites W2018840055 @default.
• W1780456323 cites W2034937449 @default.
• W1780456323 cites W2052637669 @default.
• W1780456323 cites W2066834458 @default.
• W1780456323 cites W2070351173 @default.
• W1780456323 cites W2074389568 @default.
• W1780456323 cites W2091818856 @default.
• W1780456323 cites W2093355099 @default.
• W1780456323 cites W2117852685 @default.
• W1780456323 cites W2123751165 @default.
• W1780456323 cites W2132721938 @default.
• W1780456323 cites W2147724929 @default.
• W1780456323 cites W2152311269 @default.
• W1780456323 cites W2158000191 @default.
• W1780456323 cites W2332382946 @default.
• W1780456323 cites W2407782878 @default.
• W1780456323 cites W2419432452 @default.
• W1780456323 cites W2441031247 @default.
• W1780456323 cites W2994186575 @default.
• W1780456323 doi "https://doi.org/10.1128/iai.67.7.3376-3382.1999" @default.
• W1780456323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/116520" @default.
• W1780456323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10377115" @default.
• W1780456323 hasPublicationYear "1999" @default.
• W1780456323 type Work @default.
• W1780456323 sameAs 1780456323 @default.
• W1780456323 citedByCount "30" @default.
• W1780456323 countsByYear W17804563232013 @default.
• W1780456323 countsByYear W17804563232014 @default.
• W1780456323 countsByYear W17804563232016 @default.
• W1780456323 countsByYear W17804563232017 @default.
• W1780456323 countsByYear W17804563232020 @default.
• W1780456323 crossrefType "journal-article" @default.
• W1780456323 hasAuthorship W1780456323A5004514532 @default.
• W1780456323 hasAuthorship W1780456323A5007027790 @default.
• W1780456323 hasAuthorship W1780456323A5023095988 @default.
• W1780456323 hasAuthorship W1780456323A5080303179 @default.
• W1780456323 hasAuthorship W1780456323A5086002028 @default.
• W1780456323 hasBestOaLocation W17804563231 @default.
• W1780456323 hasConcept C137061746 @default.
• W1780456323 hasConcept C150903083 @default.
• W1780456323 hasConcept C170493617 @default.
• W1780456323 hasConcept C181199279 @default.
• W1780456323 hasConcept C202751555 @default.
• W1780456323 hasConcept C203014093 @default.
• W1780456323 hasConcept C207001950 @default.
• W1780456323 hasConcept C2778513237 @default.
• W1780456323 hasConcept C2778573061 @default.
• W1780456323 hasConcept C2778754761 @default.
• W1780456323 hasConcept C28406088 @default.
• W1780456323 hasConcept C55493867 @default.
• W1780456323 hasConcept C59822182 @default.
• W1780456323 hasConcept C86803240 @default.
• W1780456323 hasConcept C89423630 @default.
• W1780456323 hasConceptScore W1780456323C137061746 @default.
• W1780456323 hasConceptScore W1780456323C150903083 @default.
• W1780456323 hasConceptScore W1780456323C170493617 @default.
• W1780456323 hasConceptScore W1780456323C181199279 @default.
• W1780456323 hasConceptScore W1780456323C202751555 @default.
• W1780456323 hasConceptScore W1780456323C203014093 @default.
• W1780456323 hasConceptScore W1780456323C207001950 @default.
• W1780456323 hasConceptScore W1780456323C2778513237 @default.
• W1780456323 hasConceptScore W1780456323C2778573061 @default.
• W1780456323 hasConceptScore W1780456323C2778754761 @default.
• W1780456323 hasConceptScore W1780456323C28406088 @default.
• W1780456323 hasConceptScore W1780456323C55493867 @default.
• W1780456323 hasConceptScore W1780456323C59822182 @default.
• W1780456323 hasConceptScore W1780456323C86803240 @default.
• W1780456323 hasConceptScore W1780456323C89423630 @default.
• W1780456323 hasIssue "7" @default.
• W1780456323 hasLocation W17804563231 @default.
• W1780456323 hasLocation W17804563232 @default.
• W1780456323 hasLocation W17804563233 @default.
• W1780456323 hasLocation W17804563234 @default.
• W1780456323 hasOpenAccess W1780456323 @default.
• W1780456323 hasPrimaryLocation W17804563231 @default.

• next